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Updated: Jan 24, 2026

Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions
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Published on: August 2, 2015

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在功能性蛋白质宇宙中探测暗能量

Ezequiel A Galpern1,2, Carlos Bueno3, Ignacio E Sánchez1,2

  • 1Protein Physiology Lab, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina.

Proceedings of the National Academy of Sciences of the United States of America
|January 22, 2026
PubMed
概括

研究人员开发了一种方法,通过分析"暗能量" - - 物理和进化自由能量之间的差异 - - 来量化蛋白质的进化约束. 这种能量定位在功能部位,揭示了蛋白质进化和功能的洞察力.

关键词:
深度突变扫描 (deep mutational scan) 是一种深度突变扫描.直接合分析直接合分析挫败感 挫败感 挫败感 挫败感大型语言模型变体效应预测变体效应预测

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