与乳房植入物相关的形大细胞淋巴瘤的发生率
Lauren S Lowe1, Dylan K Kim1, Christine H Rohde1,2
1Division of Plastic and Reconstructive Surgery, Department of Surgery, Columbia University Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Journal of the National Cancer Institute
|January 22, 2026
概括
乳房植入物相关的性大细胞淋巴瘤 (BIA-ALCL) 发病率在美国迅速增加. 最近的数据显示,BIA-ALCL诊断显著增加,超过了之前的估计.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 医疗器械 医疗器械
背景情况:
- 美国食品和药物管理局 (FDA) 授权在2020年对乳腺植入物发出黑子警告,原因是与性大细胞淋巴瘤 (ALCL) 有关.
- 世界卫生组织已将乳房植入物相关ALCL (BIA-ALCL) 视为一个独立的临时实体.
研究的目的:
- 估计在美国新诊断码引入后,美国成年女性的BIA-ALCL基于人口的发病率.
- 将当前的BIA-ALCL发病率与历史数据和之前的估计进行比较.
主要方法:
- 利用了国家癌症研究所的监测,流行病学和最终结果 (SEER) 计划数据,从2021年1月1日至2022年12月31日.
- 在使用新实施的诊断码的成年女性中诊断出BIA-ALCL确诊病例.
- 使用2000年美国标准人口计算每1亿人/年的年龄调整发病率.
主要成果:
- 根据年龄调整的BIA-ALCL发病率在2021年为每1亿人/年17.2%,在2022年为26.9%.
- 这些比率与2012-2018年估计 (14.5-19.6) 相比增加,并且大大超过2001-2007年的估计 (3).
- 这项研究表明,美国BIA-ALCL发病率迅速增加.
结论:
- 这项研究提供了第一个基于人口的BIA-ALCL发病率估计.
- 这些发现表明,在美国,BIA-ALCL病例令人担忧且迅速增加.
- 持续的监测和研究对于了解和减轻与乳腺植入物相关的风险至关重要.
相关概念视频
01:08Prevalence and Incidence
1.7K
In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
1.7K
01:21Types of Reports II: Incident or Occurrence Report
1.2K
An Incident or Occurrence Report in a healthcare setting is a crucial document used to record any unexpected occurrence that may or may not have affected a patient, employee, or visitor. Such reports are critical to improving patient safety and include all details leading up to and including the event.
Purposes:
In the healthcare industry, reports play a crucial role in documenting incidents within an agency. The primary objective of these reports is to ensure patient safety, uphold the...
Purposes:
In the healthcare industry, reports play a crucial role in documenting incidents within an agency. The primary objective of these reports is to ensure patient safety, uphold the...
1.2K
01:07What are Cells?
197.8K
Cells are the smallest and basic units of life, whether it is a single cell that forms the entire organism, e.g., in a bacterium or trillions of them, e.g., in humans. No matter what organism a cell is a part of, they share specific characteristics.
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
Furthermore, a living cell possesses genetic information...
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
Furthermore, a living cell possesses genetic information...
197.8K
02:41Concentration Cells
25.6K
A concentration cell is a type of a voltaic cell constructed by connecting two almost identical half-cells, both based on the same half-reaction and using the same electrode, differing only in the concentration of one redox species. A concentration cell's potential, therefore, is determined only by the concentration difference of the particular redox species.
Consider the following voltaic cell:
Consider the following voltaic cell:
25.6K
02:03What is Cell Signaling?
129.9K
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
129.9K
02:58Chemistry of the Cell
47.4K
The cell is chemically composed of water, organic molecules and inorganic ions.
Water
The polarity of the water molecule and its resulting hydrogen bonding makes water a unique substance with special properties that are intimately tied to the processes of life. Life originally evolved in an aqueous environment, and most of an organism’s cellular chemistry and metabolism occur inside the aqueous contents of the cell’s cytoplasm. Special properties of water are its high heat capacity...
Water
The polarity of the water molecule and its resulting hydrogen bonding makes water a unique substance with special properties that are intimately tied to the processes of life. Life originally evolved in an aqueous environment, and most of an organism’s cellular chemistry and metabolism occur inside the aqueous contents of the cell’s cytoplasm. Special properties of water are its high heat capacity...
47.4K