来自哥伦比亚波哥大萨巴纳的5500年前的Treponema pallidum基因组
Davide Bozzi1,2, Nasreen Z Broomandkhoshbacht3, Miguel Delgado4,5,6
1Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Science (New York, N.Y.)
|January 22, 2026
概括
在哥伦比亚发现了一种5500年前的Treponema基因组, 这种古老的病原体在欧洲接触和梅毒多样化之前已经存在了数千年.
科学领域:
- 古遗传学
- 进化微生物学
- 古代DNA分析
背景情况:
- 由Treponema pallidum亚种 (梅毒,,贝杰尔,平塔) 引起的病在人类中有很长的历史.
- 对于Treponema病原体的进化历史和古代多样性,人们对其了解甚少.
- 之前的研究缺乏古老的基因组数据来追踪这些细菌的深层进化历史.
研究的目的:
- 为了重建Treponema pallidum亚种的进化历史.
- 调查美洲三角膜病原体的古代存在和多样化.
- 通过使用古老的DNA扩展三角质病原体的基因组记录.
主要方法:
- 古老的DNA (aDNA) 提取和5500年前的Treponema基因组 (TE1-3) 的全基因组测序
- 基因组学分析以确定古代基因组相对于现代Treponema pallidum亚种的进化位置.
- 对基因组数据的生物信息分析,以推断种群历史和分歧时间.
主要成果:
- 在哥伦比亚的中 Holocene 狩猎采集者遗骸中发现了一种 5500 年的 Treponema 基因组 (TE1-3).
- 遗传学分析将TE1-3定位为所有已知的Treponema pallidum亚种的姐妹系.
- 这种古老的血统早于现代亚种的多样化和欧洲人的接触,
结论:
- 发现TE1-3基因组显著扩大了Treponema pallidum已知的多样性.
- 这一发现为美洲古老的三病原体存在提供了分子证据,
- 这项研究为Treponema病原体的进化和地理分布建立了一个新的分子时间表.
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