相关实验视频
Updated: Jan 24, 2026

12:10
Retzius-Sparing Robot-Assisted Radical Prostatectomy
Published on: May 19, 2022
9.1K
开发和验证一个Nomogram预测病理升级的男人与活检格莱森3+3前列腺癌进行激进前列腺切除术的发展和验证:一个基于人口的研究
Han Li1, Shuaitao Xiong1,2, Miao Wang1
1Department of Urology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
The Prostate
|January 22, 2026
概括
这项研究开发了一种名谱,用于预测格里森得分为3+3的前列腺癌的男性进行激进前列腺切除术的病理升级. 该工具的准确性中等,有助于该患者组的手术前决策.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 医疗信息学 医疗信息学
背景情况:
- 格里森评分3+3的前列腺癌患者在进行激进前列腺切除术后,病理升级是常见的.
- 准确的手术前风险识别对于预后和治疗计划至关重要.
- 这项研究解决了在这种特定患者群体中需要预测工具的需求.
研究的目的:
- 开发和内部验证用于病理升级的预测性名谱.
- 为了确定与病理升级相关的术前临床变量.
- 帮助格里森评分3+3前列腺癌的男性进行个性化手术前决策.
主要方法:
- 利用监测,流行病学和最终结果 (SEER) 数据库对14484名活检格莱森得分3+3前列腺癌患者进行了分析.
- 采用多变量逻辑回归来构建使用手术前临床数据的预测模型.
- 通过歧视 (AUC),校准 (Brier分数) 和决策曲线分析评估模型性能,通过引导和交叉验证进行内部验证.
主要成果:
- 几乎一半 (47.9%) 的患者经历了病理升级至格里森得分3+4或更高.
- 升级的关键预测因素包括年龄,前列腺特异性抗原 (PSA) 水平,阳性活检核数和临床T阶段.
- 诺米图表表现出适度的预测性能,训练队列中的AUC为0.663,验证队列中的AUC为0.648.
结论:
- 开发的诺莫图提供了适度的预测准确性,用于生检格莱森评分3+3前列腺癌的男性的病理升级.
- 这种工具可以支持进行激进前列腺切除术的患者的手术前决策.
- 进一步细化可能会提高其在临床实践中的实用性.
相关概念视频
Piaget's Stage 3 of Cognitive Development
1.0K
During Piaget's concrete operational stage, from ages 7 to 11, children exhibit a marked increase in logical thinking skills, specifically in relation to tangible, real-world events. This stage is characterized by the development of several essential cognitive concepts, including conservation, reversibility, and classification, all of which support the child's evolving capacity for structured thought.
Conservation and Constancy of Quantity
A significant cognitive milestone in the...
Conservation and Constancy of Quantity
A significant cognitive milestone in the...
1.0K
ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3
7.3K
All ortho–para directors, excluding halogens, are activating groups. These groups donate electrons to the ring, making the ring carbons electron-rich. Consequently, the reactivity of the aromatic ring towards electrophilic substitution increases. For instance, the nitration of anisole is about 10,000 times faster than the nitration of benzene. The electron-donating effect of the methoxy group in anisole activates the ortho and para positions on the ring and stabilizes the corresponding...
7.3K
Reliability and Validity
13.8K
Reliability and validity are two important considerations that must be made with any type of data collection. Reliability refers to the ability to consistently produce a given result. In the context of psychological research, this would mean that any instruments or tools used to collect data do so in consistent, reproducible ways.
13.8K
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
618
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
618
In Vitro Drug Release Testing: Overview, Development and Validation
323
In vitro dissolution and drug release tests assess how quickly and how much of a drug is released from its dosage form into an aqueous medium under standardized laboratory conditions. These tests are essential tools in pharmaceutical development and quality assurance, offering insight into the drug's performance before clinical use.During formulation development, dissolution testing identifies incomplete or inconsistent drug release issues. It also supports decisions on selecting the optimal...
323
Conservation of Small Populations
16.7K
Small population sizes put a species at extreme risk of extinction due to a lack of variation, and a consequent decrease in adaptability. This weakens the chances of survival under pressures such as climate change, competition from other species, or new diseases. Large populations are more likely to survive pressures such as these, as such populations are more likely to harbor individuals that have genetic variants that are adaptive under new stresses. Small populations are much less...
16.7K

