晚期早产前产前皮质类固醇后的儿童肺部结果
Cynthia Gyamfi-Bannerman1, Rebecca G Clifton, Robert A Wise
1Columbia University, New York, and New York Medical College, Valhalla, New York; the University of California, San Diego, La Jolla, and Stanford University, Stanford, California; the George Washington University Biostatistics Center, Washington, DC; Johns Hopkins University, Baltimore, and the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland; the University of Alabama at Birmingham, Birmingham, Alabama; the Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; the University of Texas at Austin, Austin, the University of Texas Health Science Center at Houston-Children's Memorial Hermann Hospital, Houston, and the University of Texas Medical Branch, Galveston, Texas; Brown University, Providence, Rhode Island; the University of Utah Health Sciences Center, Salt Lake City, Utah; Eastern Virginia Medical School, Norfolk, Virginia; The Ohio State University, Columbus, and MetroHealth Medical Center-Case Western Reserve University, Cleveland, Ohio; the University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado; the University of North Carolina at Chapel Hill, Chapel Hill, and Duke University, Durham, North Carolina; and Northwestern University, Chicago, Illinois.
晚期早产前产前甲没有影响儿童整体呼吸功能障碍. 然而,它与6岁及以上儿童喘息症状的减少有关.
科学领域:
- 产科和妇科 产科和妇科
- 儿科肺病学 儿科肺病学
- 新生儿医学 新生儿医学
背景情况:
- 产前皮质类固醇治疗对于胎儿肺部成熟至关重要.
- 晚期早产婴儿 (34-36周怀孕) 可能受益于产前类固醇.
- 产前类固醇的潜在长期呼吸系统影响需要评估.
研究的目的:
- 评估产前贝塔梅他对儿童呼吸系统健康的影响.
- 为了确定晚期早产期的类固醇暴露是否会影响儿童的呼吸功能障碍,直到6岁+.
主要方法:
- 从产前晚期早产类固醇 (ALPS) 试验中对儿童的前性随访.
- 年龄在6岁以上的参与者,随机分配给贝他美沙或安慰剂.
- 主要结局:综合异常的螺旋测量,用药物诊断喘,或每天使用药物.
主要成果:
- 在betamethasone和安慰剂组之间,初级复合呼吸结果没有显著差异.
- 在贝塔梅他组中观察到胸部喘息或吹口哨的发病率较低.
- 与术语对照相比,ALPS儿童的运动诱导喘息率较高.
结论:
- 晚期早产前甲暴露不会导致儿童整体呼吸功能障碍的显著差异.
- 喘息症状显著减少与产前贝他美沙有关.
- 需要进一步的研究来了解长期的呼吸道影响.
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