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Updated: Jan 24, 2026

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In Silico Clinical Trials for Cardiovascular Disease
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关注AKI - 趋势的转变是否是平台临床试验的提示?
N A Shah1, S Kotwal1, M Ostermann2
1School of Clinical Medicine, Faculty of Medicine & Health, UNSW Sydney, Sydney, NSW, Australia; Department of Nephrology, Prince of Wales Hospital, Sydney, NSW, Australia; The George Institute of Global Health, UNSW Sydney, Sydney, NSW, Australia.
Journal of critical care
|January 22, 2026
概括
脏研究正在增长,基础科学研究的显著增加,重点是急性损伤 (AKI). 这一趋势凸显了AKI机械和治疗研究的发展管道.
科学领域:
- 科和生物医学研究.
背景情况:
- 急性损伤 (AKI) 是住院的常见并发症,与显著的发病率,死亡率和医疗保健费用有关.
- 尽管它很普遍,但对AKI的有效向疗法是有限的,临床试验采用精准医学方法的速度很慢.
研究的目的:
- 分析脏相关基础科学研究的时间趋势.
- 评估这些趋势对AKI治疗的发展的影响.
主要方法:
- 在2013年1月1日至2024年12月31日期间,使用EMBASE数据库进行了脏研究出版物的映射审查.
- 出版物被分为基础科学,AKI相关,机械学或治疗研究.
- 用描述性统计和简单的回归模型分析了时间趋势.
主要成果:
- 在研究期间,脏研究总产出显示出显著的增长趋势.
- 在脏研究中,基础科学研究的比例有所下降,但以AKI为重点的基础科学研究显著增加.
- 与AKI相关的机械学和治疗学研究都有实质性的增长.
结论:
- 脏研究领域正在扩大,AKI发现科学显著增加,机理学和治疗研究的管道不断增加.
- 建议对临床试验基础设施进行投资,例如适应性平台试验,以加快将AKI研究成果转化为临床实践.
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