统计过程控制CBCT密度马分析作为离线自适应性放射治疗的临床触发器
Ping Lin Yeap1, Melvin Ming Long Chew1, Yun Ming Wong1
1Division of Radiation Oncology, National Cancer Centre Singapore, 30 Hospital Boulevard, Singapore, 168583, SINGAPORE.
Physics in medicine and biology
|January 22, 2026
概括
密度马传递率 (dGPR) 通过检测解剖变化和设置错误,有效地自动化适应性放射治疗. 统计过程控制 (SPC) 建立特定站点的值,提高治疗准确性和患者安全.
科学领域:
- 辐射瘤学 辐射瘤学
- 医学物理 医学物理
背景情况:
- 适应性辐射疗法 (ART) 旨在通过解决内部和内部断片的解剖变异来改善治疗结果.
- 商业软件可以使用密度马传递率 (dGPR) 来量化计划CT (pCT) 和束CT (CBCT) 之间的差异.
研究的目的:
- 评估dGPR作为一个自动化,特定于现场的触发器在线自适应性放射治疗工作流程的实用性.
- 使用统计过程控制 (SPC) 来定义容忍值,并将dGPR与设置错误,PTV覆盖率和纵向稳定性相关联.
主要方法:
- 对6个解剖部位的240名患者进行了回顾性分析.
- 将第一部分CBCT与使用MobiusCB计算dGPR的pCT进行比较.
- 对特定站点的耐受性极限进行SPC分析,对错误敏感性的幻影研究,以及与PTV V100%和纵向稳定性的相关性.
主要成果:
- 对于dGPR,SPC衍生的下限作用因位点而异 (大脑的97.3%,乳腺的82.2%).
- 幻影研究证实了dGPR对设置错误的敏感性,对较小体积 (例如头部与骨盆) 有更大的影响.
- 在头患者中,dGPR和PTV V100%之间的中等相关性 (r=0.56);在治疗后期的头患者中观察到逐渐的dGPR下降.
结论:
- dGPR提供了一种实用,自动化和特定站点的度量,用于检测放射治疗中的解剖变化和设置错误.
- 来自SPC的值为适应性工作流提供了强大的,定制的行动级别.
- 像MobiusCB这样的软件的自动警报减少了对主观图像审查的依赖,提高了效率和安全性.
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