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装有素的纳米复合材料通过鼻内输送毒症相关的脑病变疗法准微质细胞

Weihong Guo¹, Tao Liu², Xiaojia Peng¹

¹Department of Neurology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China.

Colloids and surfaces. B, Biointerfaces

|January 22, 2026

概括

装有素的纳米颗粒有效地将素输送到大脑,减少败血症相关脑病变 (SAE) 中的神经炎症. 这种新型的输送系统增强了氨酸的作用.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
生物技术是生物技术.

背景情况:

败血症相关脑病变 (SAE) 涉及神经炎症.
素 (LUT) 具有治疗潜力,但生物可用性较差.
药物输送方面的挑战限制了LUT在SAE中的有效性.

研究的目的:

开发含有黄素的乳二二酸盐纳米颗粒 (LUT-LF-CS NPs).
提高LUT用于SAE治疗的生物可用性.
评估LUT-LF-CSNP在SAE中减轻神经炎症的疗效.

主要方法:

优化了LUT-LF-CS NPs的尺寸和封装效率.
评估纳米复合物细胞相容性和增强LUT活动.
通过CD44受体介导的细胞内细胞吸收进行了研究.
评估了用于大脑皮层药物输送的鼻内注射.
分析了对微质极化和TLR4/MyD88/NF-κB通路的影响.

主要成果:

优化的LUT-LF-CSNP:大小为45.9纳米,封装效率为71.73%.
纳米复合材料显示出良好的细胞兼容性,并增强了LUT的抗氧化/抗炎作用.
促进了微质细胞的吸收和有效的脑部输送.
促进了M2微质极化,并抑制了TLR4/MyD88/NF-κB信号传递.

结论:

LUT-LF-CS NPs显著改善了 LUT 的神经保护作用.
这种纳米粒子配方是SAE的有前途的治疗策略.
提高生物可用性和有针对性的输送是有效性的关键.

关键词:

复合纳米粒子是一种复合纳米粒子.鼻内注射鼻内注射鼻内注射微质的极化是微质的极化神经保护是一种神经保护.有针对性的交付目标.

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