用化疗法治疗的非小细胞肺癌患者的五年生存率
Shion Kachi1, Kazuyuki Suzuki2, Reo Hamaguchi1
1Japanese Society on Inflammation and Metabolism in Cancer, 119 Nishioshikouji-cho, Nakagyo-ku, Kyoto 604-0842, Japan.
Translational oncology
|January 22, 2026
概括
含有饮食和口服补充剂的化疗法可能会改善某些IV期非小细胞肺癌 (NSCLC) 患者的生存率. 尿液pH值较高,这是一种化的标志物,与EGFR/ALK突变阴性NSCLC患者的更好的长期存活率有关.
科学领域:
- 在瘤学瘤学.
- 代谢研究研究 代谢研究
- 癌症治疗方法 癌症治疗方法
背景情况:
- 酸性瘤微环境与癌症恶性瘤,免疫逃避和抗药性增加有关.
- 化疗法,一种饮食改变和口服补充剂的组合,正在被探索作为一种抵消瘤酸性的策略.
- 了解系统性化对晚期非小细胞肺癌 (NSCLC) 存活率的影响至关重要.
研究的目的:
- 为了研究尿液pH值之间的关联,一个替代标记系统性化,和患者的长期存活 第四期非小细胞肺癌 (NSCLC).
- 要确定这种关联是否在EGFR/ALK突变阳性和EGFR/ALK突变阴性NSCLC亚组之间有所不同.
- 评估性化疗法作为高级NSCLC管理中的潜在支持措施.
主要方法:
- 在2014年至2019年间对203名连续治疗IV期NSCLC的患者进行了回顾性队列研究.
- 患者接受了标准化的化疗法 (低潜在酸负荷饮食加口服二碳酸和/或/酸).
- 计算了尿液的平均pH值,并使用Kaplan-Meier方法和Cox回归分析了生存结果,按EGFR/ALK突变状态分层.
主要成果:
- 总体5年生存率为49.0%,EGFR/ALK突变阳性 (49.9%) 和阴性 (48.6%) 组之间没有显著差异.
- 在EGFR/ALK突变阴性患者中,术后复发的结果比新发病的第四阶段疾病更好 (5年生存率为65.5%vs42.0%,p=0.02).
- 平均尿液pH≥7.5与EGFR/ALK突变阴性患者的5年生存率 (70.0%vs39.3%,p=0.04) 相关,这表明存在关联,而不是因果关系.
结论:
- 尿液pH值可以作为酸状态和晚期NSCLC潜在治疗反应的实用指标.
- 化疗法,反映在更高的尿液pH值,显示出与改善长期存活在EGFR/ALK-突变阴性IV期NSCLC的关联.
- 需要进一步的研究来探索性化策略在NSCLC治疗中的因果作用和最佳应用,特别是在特定的分子亚型中.
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