使用pH驱动方法设计含有生物活性化合物的蛋白质基纳米颗粒的最新见解:基于现有理论框架的技术进步的积极影响
Jiyao Zhang1, Alkassoumi Hassane Hamadou1, Yajing Qi1
1School of Food and Biological Engineering, Jiangsu University, Zhenjiang, Jiangsu Province 212013, China.
Food chemistry
|January 22, 2026
概括
基于pH的方法 (PDM) 提供了一种绿色的方式,可以创建基于蛋白质的纳米粒子 (NP) 载体,用于生物活性化合物 (BAC). 这种方法通过提高稳定性和生物可用性来增强功能性食品中的BAC输送.
科学领域:
- 食品科学与技术 食品科学与技术
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
背景情况:
- 越来越多的消费者对富含生物活性化合物 (BAC) 的功能性食品的需求.
- 由于生物可用性差,溶解性低和不稳定性,BAC应用的挑战.
- 需要先进的交付系统来克服这些局限性.
研究的目的:
- 审查和分析以pH驱动的方法 (PDM) 准备以蛋白质为基础的纳米粒子 (NP) 载体的进步.
- 突出封装,制造和表征技术方面的创新.
- 讨论对可扩展性,工业可行性和未来粮食发展的影响.
主要方法:
- 对基于蛋白质的NP载体的pH驱动方法 (PDM) 应用的系统文献综述.
- 分析封装策略,制造过程优化 (酸化,定制) 和辅助方法.
- 对机理阐明的伪动态表征技术的审查.
主要成果:
- 通过PDM,可以轻松地制备以蛋白质为基础的NP,具有卓越的合性质,稳定性和释放性.
- 显著的技术创新导致了各种封装方式和优化的制造细节.
- 鉴定方法现在阐明了跨pH梯度的自我组装机制.
结论:
- PDM是一个有前途的平台,可以提高BAC在功能性食品中的生物可用性和应用.
- 优化的制造和表征有助于提高可扩展性和工业可行性.
- 对剩余缺陷和未来趋势的进一步研究将推动食品开发领域的创新.
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