在患有自我限制焦点的患者中,演变为睡眠中的尖峰和波激活
Merve İriş1, Miray Atacan Yaşgüçlükal1, Cengiz Yalçınkaya1
1Department of Neurology, Cerrahpaşa Medical Faculty, Istanbul University-Cerrahpaşa, Istanbul, Turkey.
Seizure
|January 22, 2026
概括
儿童期自限焦点 (SeLFE) 可以演变为睡眠中的尖峰和波激活 (SWAS),这种情况以前被认为是良性的. 临床医生必须对这些儿科综合征中SWAS的发展保持警.
科学领域:
- 儿科神经学 儿科神经学
- 发病学 (Epileptology) 是一个专业的学科.
- 临床神经生理学 临床神经生理学
背景情况:
- 儿童期自限焦点 (SeLFE) 通常被视为良性疾病.
- 一部分SeLFE患者可能会在睡眠中发生尖峰和波激活 (SWAS).
研究的目的:
- 研究被诊断患有SeLFE综合征的儿童中SWAS发展的发生率和特征.
- 评估SWAS演变在儿科的临床影响.
主要方法:
- 对144名被诊断患有SeLFE综合征的患者 (1989-2023) 病历的回顾性分析.
- 纳入标准:ILAE 2022诊断标准,至少2年的随访,至少两次清醒/睡眠EEG.
- SWAS被定义为≥50%的NREM睡眠被尖峰和波放电所占据.
主要成果:
- 在144名SeLFE患者中,12名 (8.3%) 进化为SWAS.
- 在患有有中尖自限性 (SeLECTS),自限性自主性发作 (SeLEAS) 和儿童尾部视觉 (COVE) 的患者中发生了SWAS的发展.
- 大多数患有SWAS的患者也表现出认知/行为回归,诊断为患有SWAS (EE-SWAS) 或兰道-克莱夫纳综合征的脑病.
结论:
- 随着SELFE的分类不断发展,人们认识到它们并不统一的良性.
- 临床医生应该保持对SWAS发展潜力的认识,即使发病率很低.
- 对于患有SeLFE综合征的患者来说,早期识别和管理SWAS至关重要.
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