乳牛中形式的代谢:吸收和分泌途径
M R Nn1, N P N Rskov2, M Thorsteinsson2
1Department of Animal and Veterinary Sciences, Research Centre Foulum, Aarhus University Viborg, DK-8830 Tjele, Denmark; SEGES Innovation, DK-8200 Aarhus, Denmark.
Journal of dairy science
|January 22, 2026
概括
形式在奶牛的牛皮中迅速转化为二二甲. 这种代谢物被吸收,以高剂量分配到牛奶中,并被最小限度排泄,系统可用性较低.
科学领域:
- 动物科学动物科学
- 兽医药理学 兽医药理学
- 环境化学环境化学
背景情况:
- 了解料添加剂的吸收,分布,新陈代谢和分泌 (ADME) 对动物健康和食品安全至关重要.
- 约多被研究其在奶牛中潜在的甲缓解作用,需要ADME的表征.
研究的目的:
- 为了描述乳牛中形式ADME的特征.
- 在生物流体中量化形式及其代谢物二甲.
- 为了阐明形式和二甲的代谢命运和系统性可用性.
主要方法:
- 三个互补的实验涉及丹麦荷尔斯坦乳牛.
- 使用4x4拉丁方形设计,对经过反注射的奶牛进行剂量反应研究.
- 在试验室中,在牛体液中的降解动力学和diidomethane的体内药理动力学分析.
主要成果:
- 在所有采样矩阵中,形式度低于检测极限.
- 在小液,血液,牛奶和尿液中检测到二二甲基.
- 血清中显而易见的系统性可用性为0.1%1.8%,牛奶分布为0.06%.
- 形式在液中快速代谢为二甲 (T1/2 = 5 分钟).
结论:
- 形式在小肠中迅速转化为二二甲.
- 二甲被吸收到循环中,并以高剂量的形式转移到牛奶中.
- 滴度甲通过尿液的分泌是最小的,这表明系统暴露和分泌有限.
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