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Updated: Jan 24, 2026

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thalidezine通过破坏 lysosomal 功能触发 cathepsin B 介导的 T 细胞淋巴瘤中的细胞死亡

Yingjie Qing1, Su Xu2, Dawei Yang3

  • 1State Key Laboratory of Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Nanjing University of Chinese medicine, Nanjing, China.

Chemico-biological interactions
|January 22, 2026
PubMed
概括

一种新型 lysosomotropic 药物thalidezine 通过诱导 lysosomal 膜通透,有效地向T 细胞淋巴瘤 (TCL). 这释放了cathepsin B,启动了细胞亡,并为TCL提供了一个有前途的治疗策略.

关键词:
在CTSB中,CTSB是CTSB.在LMP中使用LMP.lysosome 是一种溶解体.Lysosomotropic 剂是一种溶解性转化剂.在 TCL TCL 中.塔利迪津 (thalidezine) 是一种酸盐.

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