Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

G-protein Coupled Receptors01:21

G-protein Coupled Receptors

131.7K
G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
131.7K
Mutations01:39

Mutations

94.4K
Overview
94.4K
Confirmation Biases01:31

Confirmation Biases

8.1K
The confirmation bias is the tendency to focus on information that confirms our existing beliefs and ignore information that is inconsistent with our expectations. For example, if you think that your professor is not very nice, you notice all of the instances of rude behavior exhibited by the professor while ignoring the countless pleasant interactions he is involved in on a daily basis. Have you ever fallen prey to the confirmation bias, either as the source or target of such bias?
8.1K
Agonism and Antagonism: Quantification01:14

Agonism and Antagonism: Quantification

1.0K
When drugs are administered, they can elicit either an agonist or antagonist effect on the body. Agonism occurs when a drug activates a specific receptor, triggering a biological response. On the other hand, antagonism happens when a drug binds to the same receptors but blocks their activation, thereby preventing a biological response.
To quantify these effects, researchers use a dose-response curve, which provides valuable information about the potency and efficacy of a drug. Potency refers to...
1.0K
Termination of Translation01:44

Termination of Translation

27.5K
The large ribosomal subunit has several important structures essential to translation. These include the peptidyl transferase center (PTC) - which is the site where the peptide bond is formed - and a large, internal, water-filled tube through which the nascent polypeptide moves. This latter structure is called the Peptide Exit Tunnel, and it begins at the PTC and spans the body of the large ribosomal subunit. During translation, as the nascent polypeptide chain is synthesized, it passes through...
27.5K
Hindsight Biases01:12

Hindsight Biases

4.2K
Hindsight bias leads you to believe that the event you just experienced was predictable, even though it really wasn’t. In other words, you knew all along that things would turn out the way they did. Can you relate this to the phrase "Hindsight is 20/20" now? 
4.2K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Head Acceleration Event Exposure during Pre-Season Training in Elite Men's Rugby Union.

Sports medicine - open·2026
Same author

What are healthcare practitioners' perspectives and experiences of strength assessment and strength training practices in community pulmonary rehabilitation? A qualitative study from the UK.

BMJ open·2026
Same author

Metabolic state determines the brain and direct islet effects of liraglutide on enhanced insulin secretion.

Diabetologia·2026
Same author

The Dark Tetrad and academic dishonesty: a systematic review and narrative synthesis of personality predictors of cheating, plagiarism, and deception in education.

BMC psychology·2026
Same author

Serum proteomic atlas reveals distinct molecular signatures of lupus nephritis activity, chronicity, and treatment response.

bioRxiv : the preprint server for biology·2026
Same author

Improving social support among sports medicine practitioners: a call to action.

British journal of sports medicine·2026

相关实验视频

Updated: Jan 24, 2026

Crystal Structure of the N-terminal Domain of Ryanodine Receptor from Plutella xylostella
11:31

Crystal Structure of the N-terminal Domain of Ryanodine Receptor from Plutella xylostella

Published on: November 30, 2018

7.9K

模拟使用GLP-1受体C端突变的G蛋白偏差激素.

Hanh Duyen Tran1, Yiming Zuo1, Carissa Wong1

  • 1Section of Endocrinology, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, Du Cane Road, W12 0NN, United Kingdom.

Molecular metabolism
|January 22, 2026
PubMed
概括

通过减少酸化来修改类似葡萄糖-1受体 (GLP-1R),可以增强G蛋白信号传递. 这种方法支持使用偏向激素来提高GLP-1R激素对2型糖尿病和肥胖症治疗的疗效.

关键词:
在GLP-1受体.有偏见的激进主义.这是一种β-arrestin.

更多相关视频

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
10:13

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding

Published on: June 9, 2017

17.2K
Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
12:09

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Published on: February 28, 2019

10.3K

相关实验视频

Last Updated: Jan 24, 2026

Crystal Structure of the N-terminal Domain of Ryanodine Receptor from Plutella xylostella
11:31

Crystal Structure of the N-terminal Domain of Ryanodine Receptor from Plutella xylostella

Published on: November 30, 2018

7.9K
Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
10:13

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding

Published on: June 9, 2017

17.2K
Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
12:09

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Published on: February 28, 2019

10.3K

科学领域:

  • 药理学 药理学是指药理学的学科.
  • 分子生物学分子生物学
  • 内分泌学 在内分泌学.

背景情况:

  • 葡萄糖类-1受体 (GLP-1R) 是2型糖尿病和肥胖症的关键标.
  • 偏差激动剂,偏好G蛋白而不是β-arrestin信号,显示出临床疗效.
  • 之前的研究面临的挑战是由于连接物性质的变化.

研究的目的:

  • 为了研究使用受体突变而不是修饰的配体的G蛋白偏差GLP-1R激素.
  • 通过抑制GLP-1R C尾酸化来模仿G蛋白偏差信号传递.

主要方法:

  • 突变的人类和小鼠GLP-1RC尾巴 (氨酸到氨酸) 抑制酸化.
  • 评估了HEK293细胞和胰腺β细胞中的β-逮捕素招募,内置和Gαs激活.
  • 使用原生GLP-1和偏差配体 (ExF1,ExD3) 的野生类型和突变受体进行比较.

主要成果:

  • 降低的C端酸化降低了GLP-1R内部化和β-arrestin招募.
  • 缺乏的GLP-1R表现出偏好的Gαs激活和增加的cAMP生成.
  • 特定的酸化位点对β-逮捕素的招募,内化和cAMP生产进行了差异调节.

结论:

  • 减少β-逮捕素招募和内部化的遗传修饰可以增强GLP-1R信号传递.
  • 这提供了支持G蛋白偏差作为提高GLP-1R激动剂疗效的策略的证据.
  • 这些发现为开发更有效的基于GLP-1R的治疗方法提供了一种新方法.