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与阿尔茨海默氏症相关的ACE变体增加了ACE1的催化活性和血管新生素II的产生

Miranda A Salvo1, Leah K Cuddy1, Dmitry Prokopenko2

  • 1Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

The Journal of biological chemistry
|January 22, 2026
PubMed
概括

血管酶转化酶 (ACE) 基因中的新阿尔茨海默病 (AD) 风险变异增加了其活性. 这导致血管新生素II的水平提高,该分子与神经退行有关,进一步涉及ACE在AD病变发生过程中.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.ангиотензин II 的使用.粉胺β-β (Aβ) 是一种氨酸 ангиотензин系统的氨酸.单核酸多态性 (SNP) 是一种单核酸多态性.

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