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Updated: Jan 24, 2026

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BMI1抑制G-四重复的DNA形成,在复制过程中保持基因组稳定性

Roy Hanna1, Eric Deneault2, Gilbert Bernier3

  • 1Stem Cell and Developmental Biology Laboratory, Hôpital Maisonneuve-Rosemont, 5415 Boul. l'Assomption, Montreal, QC H1T 2M4, Canada.

The Journal of biological chemistry
|January 22, 2026
PubMed
概括

异色素通常抑制G-四重复合体 (G4s),以防止复制压力和基因组不稳定性. 失去BMI1会破坏这一过程,导致G4形成和DNA损伤,这是前列腺综合征中出现的机制.

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