使用机器人辅助支气管镜检查获得的肺活检中的非典型组织学:自然史和临床实践
Brandon Elllis Cowan1, Mengqi Xiao2, Camilla Gomes1
1Johnson & Johnson MedTech, Robotics and Digital; University of California San Francisco, San Francisco, Department of Surgery.
The Annals of thoracic surgery
|January 22, 2026
概括
带有异常细胞的活检很可能是恶性的. 超过三分之二的这些非诊断性活检导致癌症,许多患者被转诊治疗,没有进一步的测试.
科学领域:
- 肺部病理学 肺部病理学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 活检结果中的非典型细胞通常被认为是非诊断性的.
- 研究非典型细胞的恶性瘤率和临床结果至关重要.
研究的目的:
- 在非诊断性活检标本中确定非典型细胞的自然史和恶性瘤率.
- 在活检结果中遇到非典型细胞时分析临床医生的实践模式.
主要方法:
- 一个前性的多中心机器人辅助支气管镜研究的子组分析.
- 包括带有和没有异常细胞的非诊断样本.
- 根据病变大小变化或在12个月内重复活检的定义良性/恶性结局.
主要成果:
- 在68%的非诊断性活检中,有异型细胞 (NDwA) 的恶性病被诊断为恶性病,而没有 (NDwo) 的病例为33%.
- 21%的NDwA患者被直接转诊进行癌症治疗,而NDwo.患者的这一比例为4.6%.
- 非诊断性活检中的非典型细胞显著增加了恶性瘤的可能性.
结论:
- 超过三分之二的非诊断性活检与非典型细胞最终表现为恶性瘤.
- 显著比例的非典型细胞患者在没有进一步诊断评估的情况下被转诊接受治疗.
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