饮食中的铜摄入量与呼吸道疾病死亡率之间的关联
Kaiwen Zhang1, Jiayida Nulali1, Caoxu Zhang1
1Department of Endocrinology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
The Journal of nutritional biochemistry
|January 22, 2026
概括
饮食中较高的铜摄入量与美国成年人呼吸系统疾病死亡率的降低有关. 一个最佳的摄入水平,大约1.07毫克/天,似乎最有利于降低死亡风险.
科学领域:
- 营养流行病学 营养流行病学
- 公共卫生 公共卫生
- 呼吸系统医学 呼吸系统医学
背景情况:
- 铜是许多生理过程中必不可少的微量元素.
- 通过饮食摄入必需营养素可以影响慢性疾病的风险.
- 呼吸道疾病是全球死亡的重要原因之一.
研究的目的:
- 调查美国成年人口中饮食中铜摄入量与呼吸系统疾病死亡率之间的关联.
- 确定潜在的非线性关系和铜的最佳摄入门,以确定呼吸道死亡率.
主要方法:
- 利用了1999-2018年国家健康和营养检查调查 (NHANES) 的数据,与国家死亡指数死亡率数据联系在一起.
- 采用多变量Cox比例危险模型和灵敏度分析.
- 应用受限立方线 (RCS) 来评估非线性剂量反应关系.
主要成果:
- 在500,324个人年的随访期间,共记录了580例呼吸道疾病死亡.
- 饮食中铜摄入量较高的三位数 (≥0.88 mg/d) 与较低的三位数 (<0.88 mg/d) 相比,呼吸系统疾病死亡率的危险比率明显较低.
- RCS分析表明L形的关联,保护值约为1.07毫克/天的铜摄入量. 在此值以下,摄入量增加与死亡风险降低相关 (HR=0.48);在此值以上,没有观察到显著降低 (HR=0.98).
结论:
- 在美国成年人中,饮食中的铜摄入量和呼吸系统疾病死亡率之间存在L形关联.
- 维持最佳的饮食铜摄入水平,约为1.07毫克/天,可能与呼吸系统疾病死亡风险降低有关.
- 需要进一步的研究来证实这些发现,并探索潜在的生物机制.
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