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化污泥中CEFTIZOXIME与EPS重组相关的命运:降解途径,微生物适应和毒性降低

Zhiqiang Tang¹, Hong Liu¹, Jie Luo¹

¹School of Environmental and Municipal Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China; Technical Center of Sewage Treatment Industry in Gansu, Lanzhou 730070, China; Ministry of Education Engineering Research Center of Water Resource Comprehensive Utilization in Cold and Arid Regions.

Environmental research

|January 22, 2026

概括

这项研究表明,废水处理系统如何适应第三代类抗生素ceftizoxime (CEX). 它揭示了细胞外聚合物物质 (EPS) 的重组和微生物群落的转移,有助于CEX降解并降低其毒性.

科学领域:

环境微生物学环境微生物学
污水处理污水处理污水处理
抗生素耐药性抗生素耐药性

背景情况:

对抗生素对化系统的影响的了解有限.
需要将去除途径,降解产品毒性和微生物转移联系起来.
专注于第三代头类药物,比如Ceftizoxime (CEX).

研究的目的:

系统地研究化剂对化系统的作用.
阐明CEX去除途径,降解产品的毒性和微生物群落动态.
了解细胞外聚合物质 (EPS) 在CEX缓解中的作用.

主要方法:

实验室规模测序批量反应堆处理家庭废水中含有CEX (5-20 mg/L) 的污水,持续了175天.
监测氨去除效率,CEX去除效率和EPS组成 (PN/PS比率).
阶段解决的CEX分区分析,LC-MS/MS用于降解途径,以及微生物群体分析 (16S rRNA测序).
大肠杆菌生物测试用于降解产品的毒性评估.

主要成果:

化效率随着CEX度的增加而下降 (84.1%至39.4%).
CEX的去除效率下降了 (97.2%至43.7%),但与化有积极的相关性.
总含量的EPS增加,并转向蛋白质占主导地位 (PN/PS比1.03至2.13).
在水性,EPS和细胞内阶段观察到明显的CEX分区.
微生物群落发生了转变,氨和酸盐氧化细菌的数量下降,异构基属 (例如Ferruginibacter) 的丰富.
确定了三个CEX降解途径,在中度CEX水平下产生低毒性产品.

结论:

EPS重组,微生物群落适应和生物降解是减轻化系统中CEX风险的联结机制.
细胞外聚合物质在CEX分区和转化中起着至关重要的作用.
废水处理系统通过适应性策略表现出对第三代菌素的弹性.

关键词:

抗生素降解的降解方法在Ceftizoxime中使用.细胞外聚合物质是细胞外的聚合物质.在 LCMS/MS 中使用.微生物社区结构是微生物的社区结构.化测序批量反应堆中的化测序批量反应堆

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