纳米二氧化增强的碳素甲基纤维素/聚烯胺凝复合物用于持续释放的利多卡因
Zuyong Zhang1, Jiawei Lu2, Jiawei Zhang3
1Department of Neurology, The Third People's Hospital of Hangzhou, Zhejiang, 310009, China; Jinghua academy of Zhejiang Chinese Medicine University, Jinghua 321015, China.
International journal of biological macromolecules
|January 22, 2026
概括
这项研究创造了一种新的纳米二氧化增强凝,用于持续的利多卡因输送,提高机械强度,并提供具有抗菌性能的延长局部麻醉.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 药物输送系统 药物输送系统
背景情况:
- 传统的利多卡因输送方法的持续时间很短 (<24小时).
- 需要改进的局部麻醉系统,具有长时间的疗效和增强的性能.
研究的目的:
- 开发一种纳米二氧化增强的碳素甲基纤维素/聚烯胺 (CMC/PAM/SiO2) 水凝,用于持续的利多卡因输送.
- 为了增强延长局部麻醉的机械性能和抗菌性能.
主要方法:
- 使用sol-gel和自由基聚合制造CMC/PAM/SiO2水凝的制造.
- 将不同度的纳米-SiO2 (0-1.00μg) 作为交叉连接剂.
- 水凝结构的表征,机械强度,胀,以及体外药物释放动力学 (Ritger-Peppas模型).
主要成果:
- 使用纳米-SiO2.2,增强机械强度 (拉力强度117kPa,增加588%) 和孔密度 (400%的膨胀比).
- 持续的利多卡因释放 (72小时内91.48%) 遵循Ritger-Peppas模型.
- 优化抗菌活性 (与PAM相比增加2.16倍) 和高水分保留 (24小时后67%) 在1.00微克纳米-SiO2.
结论:
- 开发的CMC/PAM/SiO2水凝为持续的利多卡因释放提供了一个机械坚固的平台.
- 水凝表现出集成的抗菌功能和长时间局部麻醉的潜力.
- 纳米-SiO2作为一个多功能交叉连接器,显著提高水凝性能.
相关概念视频
Sustainable Development
14.8K
As the human population continues to grow and use resources, we must be mindful of our planet’s natural limits. Sustainable development provides a pathway to maintain and improve human life now while also ensuring that future generations will have the resources that they need. The long-term success of sustainability efforts rests on understanding the interplay between human actions and ecological systems.
14.8K
Reinforcement
872
Positive and negative reinforcement are key concepts in operant conditioning, a learning process where the consequences of a behavior affect the likelihood of that behavior being repeated.
Positive reinforcement occurs when a behavior is followed by the presentation of a rewarding stimulus, increasing the frequency of that behavior. For example:
Positive reinforcement occurs when a behavior is followed by the presentation of a rewarding stimulus, increasing the frequency of that behavior. For example:
872
Corrosion of Reinforcement
531
The corrosion of steel reinforcement within concrete is a process influenced by the material's inherent properties and external factors. The high pH level of around 13, provided by calcium hydroxide present in concrete, initially protects the steel reinforcement by promoting the formation of a passive iron oxide layer on its surface.
However, over time and under certain conditions like carbonation, chloride ingress, and cracking this protective state can be compromised. Steel has areas with...
However, over time and under certain conditions like carbonation, chloride ingress, and cracking this protective state can be compromised. Steel has areas with...
531
Reinforcement Schedules
479
Positive reinforcement is a powerful method for teaching new behaviors to both animals and humans. B.F. Skinner demonstrated this with his experiments using rats in a Skinner box. When a rat pressed a lever, it received a food pellet. This immediate reward encouraged the rat to repeat the behavior. This method, where a reward follows every instance of the behavior, is known as continuous reinforcement. It is highly effective for establishing new behaviors quickly.
Once a behavior is learned,...
Once a behavior is learned,...
479
Reinforcements in Concrete
453
Reinforced concrete is a composite material used extensively in construction, combining the compressive strength of concrete with the tensile strength of steel. This synergy is essential as concrete, while excellent at resisting compression, is weak under tension. Steel bars, or rebars, are embedded in the concrete to handle these tensile forces. The choice of steel is strategic; it shares a similar coefficient of thermal expansion with concrete, which ensures uniformity in response to...
453
Cellulose and Pectic Polysaccharides
4.7K
Every plant cell has a cell wall that protects the cell, provides structural support, and gives the cell shape. Cellulose, the main structural component of the plant cell wall, makes up over 30% of plant matter. It is the most abundant organic compound on earth. Cellulose is an unbranched polysaccharide composed of linear chains of glucose molecules linked by β (1→4) glycosidic bonds.
As a cell matures, its cell wall specializes according to its type. For example, the...
As a cell matures, its cell wall specializes according to its type. For example, the...
4.7K


