相关实验视频

Updated: Jan 24, 2026

Neurodevelopmental Reflex Testing in Neonatal Rat Pups

Neurodevelopmental Reflex Testing in Neonatal Rat Pups

Published on: April 24, 2017

在健康检查中进行ALT触发反射AST测试:决策曲线分析

Shu-Mei Bai¹, Xu-Xiao Guo¹, Guo-Ming Zhang²

¹Department of Laboratory Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, PR China.

Clinica chimica acta; international journal of clinical chemistry

|January 22, 2026

概括

在健康检查中,ALT触发反射测试显著降低了阿斯巴胺转移酶 (AST) 测量值. 这种方法通过使用氨酸氨基转移酶 (ALT) 水平来指导AST测试来优化查,最大限度地减少不必要的测试.

科学领域:

临床生物化学临床生物化学
健康查政策卫生查政策
诊断产量优化的优化诊断产量优化

背景情况:

常规健康检查通常包括协同安排的阿斯巴酸胺转移酶 (AST) 和氨酸胺转移酶 (ALT) 测试.
在无症状个体中,通用AST检测可能会产生有限的临床价值,这促使对替代策略的评估.

研究的目的:

使用决策曲线分析 (DCA) 评估ALT触发反射AST测试的临床实用性.
确定可实施的查政策,在例行健康检查期间优化AST测试.

主要方法:

对46,059名成年人的健康检查记录进行了回顾性分析,并对ALT和AST结果进行了配对.
基于预定义的ALT值 (15-60U/L) 的反射AST测试策略的模拟.
通过DCA评估临床效用,使用性别特定的上限参考值 (URL) 定义病理性AST.

主要成果:

性别特定的ALT触发剂 (女性≥19U/L,男性≥26U/L) 在1%的值概率下,AST测试分别减少了53.3%和37.3%.
这些政策保持了高灵敏度 (女性97.9%,男性98.0%),遗漏的病理性AST病例最小 (11.7-14.9/10,000).
反射策略在各种值概率上显示出比通用测试更大的净收益.

结论:

在健康检查中,ALT触发的反射AST检测有效地减少了低产量的AST测量.
这一策略实现了实质性的测试减少,对查灵敏度的影响最小.
DCA提供了一种透明的方法来选择特定于性别的,以查为重点的AST测试政策门.

关键词:

氨酸氨基转移酶的氨酸.亚斯巴酸氨基转移酶是一种亚斯巴酸氨基转移酶.决策曲线分析的方法进行健康检查.反射测试反射测试是一种反射测试.测试利用率的测试使用率

更多相关视频

Investigating the Potential of Singly Curved Thin Piezoelectric Transducers for Energy Harvesting and Structural Health Monitoring

Investigating the Potential of Singly Curved Thin Piezoelectric Transducers for Energy Harvesting and Structural Health Monitoring

Published on: November 14, 2025

Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents

Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents

Published on: September 10, 2018

相关概念视频

Sieve Analysis and Grading Curves

Sieve Analysis and Grading Curves

Sieve analysis is a method used to determine the particle size distribution of aggregate materials. This process involves the following steps:

Bending of Curved Members - Strain Analysis

Bending of Curved Members - Strain Analysis

The mechanics of deformation in curved members, such as beams or arches, under bending moments, involve complex responses. When such a member, symmetric about the y-axis and shaped like a segment of a circle centered at point C, is subjected to equal and opposite forces, its curvature and surface lengths change significantly. This alteration results in the shift of the curvature's center from C to C', indicating a tighter curve.
The important part of bending analysis for such a member...

Precipitation Titration Curve: Analysis

Precipitation Titration Curve: Analysis

The precipitation titration curve demonstrates the change in concentration of one reactant with the volume of titrant added. During the titration of chloride ions with silver nitrate, the precipitation titration curve is divided into three regions: before, at, and after the equivalence point. Before the equivalence point, low redissolution of the sparingly soluble silver chloride precipitate gives a low silver ion concentration. However, in the second region, representing the equivalence point,...

The Micturition Reflex

The Micturition Reflex

Urination, or micturition involves the coordination of the bladder's detrusor muscle and two sphincters to ensure controlled bladder emptying.
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...

Reflex Activity

Reflex Activity

A reflex activity is an automatic, involuntary response to specific stimuli. It is a part of our survival mechanism, designed to protect us from potential harm. For example, when a bright light suddenly shines into our eyes, we instinctively close them or look away. This is a simple reflex activity orchestrated by the nervous system without conscious thought or effort.
A reflex exam is a diagnostic procedure performed by a healthcare professional to evaluate the functionality of a patient's...

Protein Folding Quality Check in the RER

Protein Folding Quality Check in the RER

ER is the primary site for the maturation and folding of soluble and transmembrane secretory proteins. The calnexin cycle is a specific chaperone system that folds and assesses the confirmation of N-glycosylated proteins before they can exit the ER lumen. The primary players of this quality check pipeline are the lectins, ER-resident chaperones, and a glucosyl transferase enzyme. In case the calnexin system in the lumen fails to salvage a misfolded protein, it is transported to the cytoplasm...