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相关概念视频

Digestive Functions of the Large Intestine01:20

Digestive Functions of the Large Intestine

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The large intestine is where the final stages of digestion happen. When the cecum receives chyme, it contains undigested carbohydrates that undergo fermentation. Gut bacteria ferment these carbohydrates to produce short-chain fatty acids that provide some energy and help synthesize essential vitamins.
As the chyme moves to the colon, it triggers two characteristic sluggish contractions - haustral churning and mass peristalsis. Haustral churning involves the rhythmic contraction and relaxation...
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Epithelial Tissues and Their Functions01:23

Epithelial Tissues and Their Functions

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Epithelial tissues are large sheets of cells covering all of the surfaces of the body. These surfaces can be internal or external, for example, skin, airways, the digestive tract, the urinary system, and the reproductive system. Hollow organs and body cavities that do not connect to the body's exterior, including blood vessels and serous membranes, are lined by epithelial tissue known as the endothelium.
Epithelial tissues provide the body's first line of protection from physical,...
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Anatomy of the Intestines01:23

Anatomy of the Intestines

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Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
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Household Wiring And Electrical Safety01:13

Household Wiring And Electrical Safety

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Companies that supply power to most modern households use three conductors, typically called a three-wire line. While one is neutral, the other two are both at 120 V but with opposite polarity, giving a voltage of 240 V between them. With a three-wire line, high-power appliances that require 240 V, such as electric stoves and clothes dryers, are linked between the two hot lines. 120 V appliances can be connected between the neutral and either of the hot lines. The neutral side, which is always...
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Magnetic Field Due To A Thin Straight Wire01:28

Magnetic Field Due To A Thin Straight Wire

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Consider an infinitely long straight wire carrying a current I. The magnetic field at point P at a distance a from the origin can be calculated using the Biot-Savart law.
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Magnetic Field Due to Two Straight Wires01:18

Magnetic Field Due to Two Straight Wires

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Consider two parallel straight wires carrying a current of 10 A and 20 A in the same direction and separated by a distance of 20 cm. Calculate the magnetic field at a point "P2", midway between the wires. Also, evaluate the magnetic field when the direction of the current is reversed in the second wire.
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相关实验视频

Updated: Jan 24, 2026

In Vitro and In Vivo Approaches to Determine Intestinal Epithelial Cell Permeability
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In Vitro and In Vivo Approaches to Determine Intestinal Epithelial Cell Permeability

Published on: October 19, 2018

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神经元VIP连接了肠道上皮细胞的功能.

Ziad Al Nabhani1, Valentin Thevin1, Luisa Morelli1

  • 1Department of Visceral Surgery and Medicine, Bern University Hospital, Bern, Switzerland; Maurice Müller Laboratories, Department for Biomedical Research, University of Bern, Bern, Switzerland.

Mucosal immunology
|January 22, 2026
PubMed
概括

神经元衍生的血管活性肠 (VIP) 通过控制肠道细胞发育和免疫平衡来调节肠道健康. 这种受体相互作用保护了肠道屏障,并影响了免疫力.

科学领域:

  • 免疫学 免疫学 免疫学
  • 神经科学是一个神经科学.
  • 胃肠病学 胃肠病学

背景情况:

  • 肠表皮和免疫系统对于维持肠道平衡至关重要.
  • 肠道功能的神经调节得到越来越多的认可,但尚未完全理解.

研究的目的:

  • 研究神经元衍生的血管活性肠 (VIP) 在调节肠上皮分化的作用.
  • 为了阐明VIP如何在肠道内调节免疫反应.
  • 了解VIP对肠道屏障完整性的贡献机制.

主要方法:

  • 利用小鼠模型研究VIP信号在肠道中的影响.
  • 研究了肠道表皮中的基因表达和细胞分化.
  • 分析了免疫细胞种群和细胞因子概况.
  • 研究了VIP受体VIPR1.1的功能.

主要成果:

  • 神经元衍生的VIP抑制了肠道上皮层中分泌细胞系的扩张.
  • 通过VIPR1的VIP信号,平衡了1型和2型免疫反应.
  • VIP建立了一个神经上皮电路,这对于保持肠道屏障完整性至关重要.

结论:

关键词:
肠道神经元 肠道神经元肠道上皮细胞是肠道上皮细胞.第二种类型的免疫.一个VIP的VIP的VIP的

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Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
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Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

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Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells
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Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
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  • 神经元衍生的VIP是肠上皮分化和免疫恒常的关键调节者.
  • VIP通过神经上皮电路在维持肠道屏障功能方面发挥着至关重要的作用.
  • 针对VIP信号可能为炎症和与障碍相关的肠道疾病提供治疗潜力.