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Updated: Jan 24, 2026

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
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一种调节细胞死亡信号的小分子TNF-α-TNFR1抑制剂的结构和分子特征

Hana Seo1, Muhammad Haseeb1, Sangdun Choi2

  • 1Department of Molecular Science and Technology, Ajou University, Suwon 16499, South Korea; S&K Therapeutics, Ajou University Campus Plaza 418, Worldcup-ro 199, Yeongton-gu, Suwon 16502, South Korea.

Biochemical pharmacology
|January 22, 2026
PubMed
概括

一种新型的小分子TI-16抑制了瘤亡因子-α (TNF-α) 和它的受体 (TNFR1) 之间的相互作用. 这种方法为炎症和自身免疫性疾病的生物疗法提供了一个有希望的替代方案.

关键词:
细胞灭亡 (apoptosis) 是一种死亡的过程.引发炎症的信号提供.分子动力学模拟模型尸体灭 (Necroptosis) 是一种死亡的过程.小分子抑制剂小分子抑制剂瘤亡因子受体1 瘤亡因子受体1瘤亡因子-阿尔法

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