电针通过抑制cGAS-STING通路减轻老鼠的神经炎症和术后认知功能障碍
Baobao Ma1,2,3, Shiwen Fan1,4, Jiaojiao Deng1
1Department of Anesthesiology, First Affiliated Hospital, Shihezi University, Shihezi 832003, China.
Experimental neurobiology
|January 22, 2026
概括
电针 (EA) 通过抑制cGAS-STING通路并减少神经炎症,可以缓解老老鼠的术后认知功能障碍 (POCD). 这项研究表明EA是管理POCD的有希望的非药理学策略.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 整合和补充医学是整合和补充医学.
背景情况:
- 手术后认知功能障碍 (POCD) 是老年患者的一种严重并发症,通常与手术诱导的神经炎症有关.
- 干扰素基因 (cGAS-STING) 循环GMP-AMP合成酶刺激通路是先天免疫的关键调节者,并与神经炎症有关.
研究的目的:
- 通过调节海马体cGAS-STING通路,研究电针 (EA) 是否可以改善老老鼠的POCD.
- 评估EA对神经炎症和认知功能在POCD大鼠模型中的影响.
主要方法:
- 通过使用sevoflurane麻醉和脊髓切除术建立了一个老鼠POCD模型.
- 用莫里斯水迷宫测试来评估认知功能.
- 分析了cGAS-STING通路组件 (cGAS,STING,IRF3,NF-κB,IL-1β) 的海马表达和局部化,这些组件是通过西斑和免疫光学分析的.
主要成果:
- POCD大鼠表现出显著的空间记忆障碍和cGAS,STING,NF-κB,IRF3和IL-1β的海马表达增加.
- 发现cGAS和STING蛋白与海马中的神经元共同定位.
- EA治疗部分扭转了这些认知缺陷和分子变化,这种效应反映在cGAS抑制中.
结论:
- 电可以有效地缓解老老鼠的POCD.
- 该机制涉及马cGAS-STING通路激活的抑制,并随后减少神经炎症.
- 美国医学会提出了一种潜在的非药物治疗策略,用于管理POCD.
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