在患有慢性心力衰竭的老鼠中,Xijiaqi Formula通过抑制神经炎症和促进神经可塑性来减轻认知功能障碍
Jie Chen1, Xuefen Wu1, Qian Zhang1
1Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.
Chinese journal of natural medicines
|January 22, 2026
概括
奇佳奇配方 (XJQ) 通过减少神经炎症和通过PDE4/cAMP通路增强突触可塑性,改善慢性心力衰竭 (CHF) 鼠的认知功能.
科学领域:
- 心血管医学 心血管医学
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 慢性心力衰竭 (CHF) 与认知障碍有关.
- 传统中医药Xijiaqi配方 (XJQ) 用于心脏梗塞,可以改善认知能力.
- 在治疗心衰竭后认知功能障碍时,XJQ的精确机制尚未完全理解.
研究的目的:
- 为了研究XJQ对CHF大鼠认知功能障碍的影响.
- 阐明XJQ治疗作用的潜在分子机制.
主要方法:
- 在老鼠中诱导了CHF;随后接受了XJQ治疗.
- 评估心脏和认知功能使用心声回声学,血液动力学参数,莫里斯水迷宫和开放场测试.
- 网络药理学,分子对接和生物化学分析被用来识别活性成分和信号通路.
主要成果:
- 在CHF大鼠中,XJQ治疗改善了心脏和认知功能.
- XJQ调节了突触功能,炎症以及PDE4/cAMP信号通路.
- 通过影响cAMP通路中的关键蛋白质,XJQ抑制了微质和天体细胞激活,减少了促炎性细胞因子,并促进了突触修复.
- 特定的XJQ组件直接与PDE4.4结合.
结论:
- 在CHF大鼠中,XJQ缓解神经炎症并增强突触可塑性.
- XJQ对认知功能障碍的治疗作用通过PDE4/cAMP/PKA/CREB信号通路进行介导.
- 这项研究提供了关于心脑轴和XJQ用于治疗CHF相关认知问题的药理基础的见解.
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