维生素D补充剂使用与认知功能之间的关联:一个纵向队列研究.
Rong Hua1,2, Chun Sing Lam2, Vincent Chung Tong Mok3,4,5
1School of Nursing, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
BMJ open
|January 22, 2026
概括
维生素D补充剂并没有减缓具有足够维生素D水平的老年人的认知衰退. 医疗保健提供者应在没有明确指示的情况下建议谨慎服用补充剂.
科学领域:
- 老年学是一门学科.
- 营养神经科学 营养神经科学
- 公共卫生 公共卫生
背景情况:
- 将维生素D补充与认知结果联系在一起的证据仍然有限且相互矛盾.
- 研究维生素D补充剂对老年人认知功能的实际影响至关重要.
研究的目的:
- 为了检查维生素D补充剂使用与随后的认知功能在美国老年成人人口之间的纵向关联.
主要方法:
- 未来的队列研究利用来自健康和退休研究 (HRS) 波12-15的数据.
- 包括5065名美国老年人 (平均年龄67.5岁),在6年内评估认知功能.
- 线性混合模型被用来估计认知得分的变化,调整共变量.
主要成果:
- 与非使用者相比,维生素D补充剂的使用者表现出整体认知功能 (差异: -0.052点/年) 和执行功能 (差异: -0.021点/年) 的加速下降.
- 这种加快的下降特别观察到补充剂使用者具有正常的血清25(OH) D基线水平.
- 在维生素D水平不足或缺乏维生素D的人群中,维生素D补充剂和认知能力下降之间没有发现显著的关联.
结论:
- 补充维生素D似乎无法预防或减缓具有足够维生素D状态的老年人认知衰退.
- 对于老年人服用维生素D补充剂的建议应谨慎作出,优先考虑饮食摄入量和阳光照射.
- 需要进一步的研究来澄清维生素D在认知健康中的作用,并确定适当的补充策略.
更多相关视频
05:53Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
10.6K
08:58Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
Published on: January 5, 2017
12.8K
相关概念视频
Longitudinal Studies
487
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
487
Longitudinal Research
13.2K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
13.2K
Genome-wide Association Studies-GWAS
15.4K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
15.4K
Cognitive Dissonance
36.8K
Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
36.8K
Vitamins
2.3K
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
2.3K
Association Areas of the Cortex
9.1K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
9.1K
