在MADDY随机对照试验中,多营养补充剂在ADHD儿童中降低了亲和抗炎性免疫因子
Jennifer M Loftis1,2, Hayleigh K Ast2, Alisha M Bruton2
1Veterans Affairs Portland Health Care System, OR, USA.
Journal of attention disorders
|January 22, 2026
概括
患有ADHD的儿童多营养补充剂改变了免疫因子,特别是降低了Interleukin-5和Interleukin-13水平. 这些变化表明多种营养素和T助手2型 (Th2) 免疫反应在ADHD之间存在潜在的联系.
科学领域:
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
- 儿童精神病学 儿童精神病学
背景情况:
- 单个营养素会影响炎症,但综合多营养素补充剂对免疫因素的影响在很大程度上仍未被探索.
- 注意缺陷/多动障碍 (ADHD) 与免疫特征的改变有关,这表明免疫调节的潜在作用.
研究的目的:
- 研究8周多营养素 (维生素,矿物质,抗氧化剂,氨基酸) 补充对ADHD儿童免疫因子的影响.
- 为了比较多营养组和安慰剂组之间的免疫因素变化.
主要方法:
- 一项随机对照试验,涉及83名被诊断患有多动症的儿童.
- 采用多重技术,在基线和8周补充后测量了25种免疫因子.
- 统计分析包括曼-惠特尼试验,线性混合效应模型和DAVID路径分析.
主要成果:
- 与安慰剂相比,多营养素补充剂显著改变了互白素-5 (IL-5) 和互白素-13 (IL-13) 的水平.
- 在多营养组中,IL-13的水平显著下降,而IL-5的水平在不同组之间有所不同.
- 路径分析表明,T助手2型 (Th2) 信号路径受到多营养素干预的影响.
结论:
- 多营养补充剂可能会影响儿童的Th2免疫因子.
- 这些免疫调节可能与ADHD的行为改善有关,需要进一步调查.
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