用人工智能管理临床实践指南中的利益冲突:从大型语言模型和超越的洞察力
Ye Wang1,2,3,4, Qi Wang5, Yangqin Xun6
1School of Public Health, Lanzhou University, Lanzhou, Gansu, China.
Journal of evidence-based medicine
|January 22, 2026
概括
大型语言模型 (LLM) 可以通过改善数据收集和客观性来加强临床实践指南 (CPG) 开发中的利益冲突 (COI) 管理. 然而,伦理考虑和现实世界的验证对于它们的成功实施至关重要.
科学领域:
- 医疗保健中的人工智能
- 临床实践指南开发 临床实践指南开发
- 科学完整性 科学完整性
背景情况:
- 利益冲突 (COI) 管理对于临床实践指南 (CPG) 的完整性和公平性至关重要.
- 大型语言模型 (LLM) 具有显著的潜力,可以在CPG开发中增强COI管理流程.
研究的目的:
- 研究LLM在CPG开发过程中的利益冲突管理中的应用.
- 确定LLM整合在CPG的COI管理中的挑战和未来方向.
主要方法:
- 模拟的COI场景是根据既定的管理原则设计的.
- 在这些模拟场景中测试了LLM的能力,以评估它们对COI管理的支持.
主要成果:
- 法律法规证明了提高数据收集效率 (例如,披露分析) 和提高风险评估客观性的潜力.
- 隐私风险 (例如,数据泄露) 和技术挑战 (例如,模型偏差) 被确定为采用障碍.
- 政策框架,研究合作和加强的安全措施 (例如,差异隐私) 可以提高LLM的可靠性.
结论:
- 在CPG开发中,LLM可以有效地支持COI管理,前提是要考虑道德问题.
- 在现实环境中进一步验证基于LLM的方法是必要的.
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