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Updated: Jan 24, 2026

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高度低氧和低氧症:病原和管理
Chunmei Cai1, Guohua Ni2, Lei Chen2
1Research Center for High Altitude Medicine, School of Medical, Qinghai University, Xining, Qinghai, PR China. caicm@qhu.edu.cn.
Signal transduction and targeted therapy
|January 22, 2026
概括
像AMS,HACE和HAPE这样的高海拔疾病是由于适应不良而导致的. 本综述探讨了它们的机制,危险因素和治疗方法,包括传统藏医药.
科学领域:
- 环境生理学环境生理学
- 高度医学 高度医学
- 病理生理学 病理生理学
背景情况:
- 高海拔 (>2500米) 每年影响8000万居民和100万游客.
- 低压性低氧在海拔高度触发生理反应,但不充分或过度适应会导致不适应气候和高度疾病.
- 高度疾病的范围从急性 (AMS,HACE,HAPE) 到慢性 (CMS,HAPH),源于适应问题.
研究的目的:
- 审查关于高海拔疾病临床表现,流行病学和风险因素的当前知识.
- 系统地讨论最近的病理生理机制,重点关注遗传易感性和慢性海拔疾病 (CMS,HAPH).
- 提供预防和治疗策略的全面概述,强调自然和传统藏医药.
主要方法:
- 临床表现,流行病学,风险因素和病理生理学的文献综述.
- 系统地讨论最近的病理生理机制,包括遗传因素.
- 目前预防和治疗策略的概述,重点是天然药物.
主要成果:
- 根据适应能力,高海拔疾病被分类为急性 (AMS,HACE,HAPE) 或慢性 (CMS,HAPH).
- 病理生理机制,特别是慢性疾病和遗传易感性,正在进行调查.
- 自然药物,特别是传统的西藏疗法,在预防和治疗方面表现有前途.
结论:
- 目前尚不完全了解高海拔疾病背后的机制,管理选择仍然有限.
- 需要进一步的研究来阐明致病机制,并改进预防和治疗策略.
- 探索遗传易感性和新的治疗方法,包括传统药物,对于推进高空疾病管理至关重要.
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