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Updated: Jan 24, 2026

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复活的基酶在20亿年的时间里重复了公认的N-同位素生物标志
Holly R Rucker1, Kunmanee Bubphamanee2, Derek F Harris3
1Department of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA.
Nature communications
|January 22, 2026
概括
科学家们研究了古老的酶酶,以了解生命的早期. 该研究发现,同位素标志一直保持一致,支持早期生命和天体生物学研究.
科学领域:
- 生物地质化学生物地质化学
- 进化生物学 进化生物学
- 天体生物学 天体生物学
背景情况:
- 沉积岩中的同位素分离 (ε15N) 表明了早期地球上的生物固定和初级生产力.
- 分子进化对酶的同位素特征的影响尚不清楚.
研究的目的:
- 在20亿年的进化过程中,重建和实验性地描述祖先的酶基因.
- 为了评估得到的 ε15N 值,以了解酶不变性.
主要方法:
- 合成祖先酶基因图书馆的重建.
- 在受控的实验室条件下对工程菌株进行实验性表征.
- 对 ε15N 值的测量.
主要成果:
- 所有工程菌株都在狭窄范围内显示了e15N值,类似于现代微生物.
- (Mo) 依赖的化酶在整个进化历史上自从该途径的起源以来似乎基本不变.
结论:
- 支持化酶的早期起源.
- 表明古代岩石中同位素生物标记的弹性.
- 突出了酶研究在寻找外星生命的潜力.
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