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Updated: Jan 24, 2026

Visualization of Endoplasmic Reticulum Localized mRNAs in Mammalian Cells
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Published on: December 17, 2012

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激活的CD8+ T细胞中的元不稳定的mRNA是由相互连接的AU丰富元素和m6A mRNA甲基化定义的

Paulo A Gameiro1,2,3, Iosifina P Foskolou4,5,6,7, Yumna A Butt5,6

  • 1The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, UK.

Nature communications
|January 22, 2026
PubMed
概括

N6-甲基氨酸 (m6A) RNA修饰和富含AU元素 (AREs) 控制CD8+ T细胞中的mRNA衰变. 这种交叉关系通过在T细胞激活过程中破坏特定mRNA的稳定来调节免疫反应.

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