由肠道微生物驱动的结直肠癌通过免疫,代谢,神经和内分泌轴重新编程
Jhommara Bautista1,2,3, Mónica Lamas-Maceiras2,3, Camila Hidalgo-Tinoco1
1Cancer Research Group (CRG), Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador.
NPJ biofilms and microbiomes
|January 22, 2026
概括
结肠直肠癌 (CRC) 是由肠道微生物驱动的,这些微生物会重新编程瘤的微环境. 新兴的战略针对预防和治疗CRC的微生物组.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 结肠直肠癌 (CRC) 是一个主要的全球健康问题.
- 肠道微生物组在CRC的发展和进展中起着至关重要的作用.
- 主体-微生物相互作用越来越被认为是CRC的关键驱动因素.
研究的目的:
- 审查关于肠道微生物组在CRC中的作用的分子,生态和转化证据.
- 解释微生物群落如何影响瘤微环境.
- 突出针对微生物的预防和治疗CRC的策略.
主要方法:
- 综合当前的科学文献.
- 分子和生态数据的分析.
- 翻译证据的整合.
主要成果:
- 与CRC相关的失生症涉及致病生物的丰富和有益的共生动物的丧失.
- 微生物通过DNA损伤,屏障破坏和炎症促进致癌.
- 细菌代谢产物在人类癌症基因组中产生特定的突变特征.
- CRC被概念化为一种由微生物驱动的生态系统疾病.
结论:
- 肠道微生物组是CRC病变发生的一个因果因素.
- 针对微生物群的策略为精确的CRC预防和治疗提供了潜力.
- 微生物组应被认为是CRC中可处理的决定因素.
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