在老年人中,双极性障碍的谱系
Lisa T Eyler1, Federica Klaus2, Angelina Van Dyne3
1Department of Psychiatry, University of California San Diego, La Jolla, CA, USA. lteyler@health.ucsd.edu.
概括
老年双相情感障碍 (OABD) 带来了独特的挑战,包括更大的认知障碍和体质负担. 全球研究合作对于了解双相情感障碍 (BD) 的衰老和改善健康状况至关重要.
科学领域:
- 老年精神病学是一门精神病学专业.
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 全球人口正在老龄化,这导致老年双相情感障碍 (OABD) 的预期增加.
- 了解OABD对于改善双相情感障碍 (BD) 患者的健康状况至关重要.
研究的目的:
- 审查关于OABD的当前知识,包括其临床表现,神经生物学和治疗.
- 确定OABD的研究缺口和未来方向.
主要方法:
- 文献综述总结了关于OABD的现有研究.
- 检查临床特征,神经生物学发现和治疗策略.
- 强调全球研究合作的作用,如GAGE-BD和ENIGMA-BD.
主要成果:
- 与较年轻的双相情感障碍 (YABD) 相比,OABD的特点是更大的认知障碍和体力负担.
- 在BD衰老中的疾病轨迹是混合的,有些人显示加速衰老;生物标志物研究显示年龄特定的变化.
- 是第一线治疗,但对OABD的大规模,年龄特定的试验有限.
结论:
- 需要根据年龄调整的临床策略来解决OABD的功能结果.
- 纵向研究和全球联盟对于确定预测因素和指导预防策略至关重要.
- 早期干预和全球合作的终身方法是促进OABD福祉的关键.
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