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Updated: Jan 24, 2026

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans
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Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Published on: November 26, 2017

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针对与年龄相关的LINE-1激活减轻心脏衰老

Chaofan Yang1,2,3, Heng Du1,2,3, Siqi Liu1,2,3

  • 1State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.

Nature aging
|January 22, 2026
PubMed
概括

长间隔的核元素-1 (LINE-1) 逆转移子通过cGAS-STING激活驱动心脏衰老和功能障碍. 抑制LINE-1或STING显示了与年龄相关的心脏病的治疗潜力.

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Cellular Clock Theory
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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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