在巨细胞动脉炎患者中双眼视的流行:系统性审查和元分析
Thanansayan Dhivagaran1, Fahad R Butt1, David Nasri2
1Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.
Eye (London, England)
|January 22, 2026
概括
双眼视,或双视,影响超过7%的巨细胞关节炎 (GCA) 患者. 这种症状最常与体神经问题有关,这表明在新成年双眼视障病例中应考虑GCA.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 类风湿病学 类风湿病学
背景情况:
- 滴是巨细胞关节炎 (GCA) 的罕见但显著的早期症状.
- 它可以先于更严重的视觉障碍,包括视力丧失.
- 了解GCA中双眼盲的患病率对于及时诊断至关重要.
研究的目的:
- 评估在被诊断为GCA的患者中双眼视的综合患病率.
- 根据神经 (CN) 干扰来分层双眼盲的患病率.
- 评估偏差风险对流行率估计的影响.
主要方法:
- 在MEDLINE,Embase和Cochrane CENTRAL数据库中进行了系统的文献搜索.
- 包括50项涉及21,680名GCA患者的研究数据.
- 进行了一项随机效应元分析,以汇集流行数据.
主要成果:
- 在GCA患者中,双眼视的整体综合患病率为7.15%.
- 患病率因神经受影响而有所不同:CN VI (1.41%),CN III (0.96%) 和CN IV (0.30%).
- 除了高风险偏差研究,类似的患病率为7.14%.
结论:
- 双流症在7%以上的GCA患者中存在,腹部神经麻是最常见的原因.
- 在成年人中新出现的双眼视障碍需要考虑GCA.
- 需要进一步的研究来澄清病因和早期识别对视觉结果的影响.
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