认知障碍与侵袭性淋巴瘤中改变的血细胞样本有关
Delyse McCaffrey1,2, Priscilla Gates3,4,5, Haryana M Dhillon6
1Laboratory of ImmunoPsychiatry, Neuroscience Research Australia, Randwick, NSW, Australia.
概括
淋巴瘤患者的认知障碍与血细胞标记物如中性粒细胞与淋巴细胞的比率 (NLRs) 和全身免疫炎症指数 (SIIs) 有关. 这些生物脆弱性在化疗中持续存在,影响客观表现,但并不总是影响主观幸福感.
科学领域:
- 神经科学是一个神经科学.
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 认知和心理症状在神经精神疾病中很常见,并且与血细胞参数有关.
- 中性粒细胞与淋巴细胞的比率 (NLRs),全身免疫炎症指数 (SIIs) 和血小板与淋巴细胞的比率 (PLRs) 是已知的炎症标志物.
- 这些血细胞参数与血液癌症的认知功能之间的关联仍未得到充分研究.
研究的目的:
- 研究具有侵略性淋巴瘤的个体的认知和心理发病率和血细胞参数之间的相关性.
- 为了评估这些关联在化疗治疗之前,期间和之后.
- 将发现与健康对照进行比较,以确定特异性.
主要方法:
- 对淋巴瘤患者 (n=30) 进行神经心理测试和自我报告问卷,在诊断时,化疗中期和治疗后进行.
- 使用回归模型分析认知功能与血细胞参数 (NLR,SII,PLR) 之间的关联.
- 引导皮尔森相关性检查了血细胞参数和心理症状之间的关系;在健康对照组 (n=72) 中进行了类似的分析.
主要成果:
- 在淋巴瘤患者中,NLR,SII和PLR与所有时间点的抑制控制,认知灵活性,延迟回忆和工作记忆的损伤相关 (p<0.05).
- 在客观认知表现和主观自我报告之间观察到一个显著的脱节.
- 较低的NLR,SII和PLR与较差的客观认知相关,但在诊断时更好地感知认知;中期化疗中较高的NLR与更糟糕的延迟回忆相关,但报告的抑郁/焦虑症状较少.
结论:
- 攻击性淋巴瘤的认知障碍与特定的血细胞参数有关,反映了化学疗法期间不同的生物功能障碍模式.
- 客观认知缺陷和主观报告之间观察到的差异凸显了将生物标志物纳入认知评估的必要性.
- 在健康对照组中没有发现任何显著的关联,这强调了这些发现对淋巴瘤患者群体的特异性.
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