评估外科医生领导的管道癌 in situ 计划对内分泌治疗吸收的影响
Monika K Masanam1,2,3,4, Olga Kantor1,2,3,5, Olivia Pappas Brunco2
1Division of Breast Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA.
Annals of surgical oncology
|January 22, 2026
概括
一个由外科医生领导的在位导管癌 (DCIS) 计划没有增加整体内分泌疗法 (ET) 的吸收. 然而,处方模式发生了变化,在绝经后的妇女中偏爱他莫西芬而不是芳香酶抑制剂.
科学领域:
- 在瘤学瘤学.
- 乳腺癌研究研究 乳腺癌研究
- 临床试验分析
背景情况:
- 内分泌疗法 (ET) 在外科手术后为管道癌 in situ (DCIS) 提供了临床益处,但吸收仍然不够理想.
- 一个由外科医生领导的DCIS计划于2021年4月实施,以解决ET利用率低的问题.
研究的目的:
- 评估外科医生领导的DCIS计划对内分泌治疗吸收的影响.
- 分析项目实施后ET处方模式的变化.
主要方法:
- 从2016年1月到2024年7月接受DCIS手术的患者的回顾性分析.
- 历史队列和DCIS程序队列之间的ET吸收的比较,使用奇平方分析.
主要成果:
- 对于雌激素受体阳性 (ER+) DCIS的整体ET吸收保持稳定 (45.7%与45.1%对比).
- 在经过乳房保护手术 (BCS) 的ER+DCIS的绝经后妇女中,他莫西芬使用量显著增加 (31.1%至56.9%),而AI使用量则减少 (67.3%至43.1%).
- 在2023年引入低剂量他莫西芬导致高采用 (91.9%的符合条件的患者).
结论:
- 由外科医生领导的DCIS计划保持了稳定的ET吸收,但改变了处方偏好.
- 经过BCS接受ER+DCIS的绝经后妇女显示,因低剂量配方的可用性而受到影响,对他莫西芬的转变显著.
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