综合网络毒理学,机器学习和生物信息学分析显示,在结直肠癌中,脱乙酸诱导的凝血功能障碍是结直肠癌
Zhenzhen Yang1,2, Cheng Chang3, Liya Jiang3
1The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People's Hospital), Zhengzhou, P.R. China.
Drug and chemical toxicology
|January 22, 2026
概括
脱乙酸盐 (SDA) 是一种环境污染物,破坏凝血. 这项研究将Met原瘤基因 (Met) 确定为关键目标,为SDA诱导的凝血功能障碍和潜在的治疗策略提供了洞察力.
科学领域:
- 环境毒理学环境毒理学
- 血液学 血液学 血液学
- 计算生物学是一种计算生物学.
背景情况:
- 凝血功能障碍是一种常见的血液学疾病,环境影响不明.
- 脱水酸 (SDA) 是一种新出现的污染物,与免疫系统破坏和凝血异常有关.
- 需要阐明SDA诱导的凝血功能障碍的精确机制.
研究的目的:
- 使用综合计算方法系统地研究脱乙酸盐 (SDA) 诱导的凝血功能障碍的机制.
- 确定受SDA暴露影响的关键分子标和途径.
- 探索已识别的目标在凝血障碍的诊断潜力.
主要方法:
- 使用了网络毒理学,机器学习 (LASSO,XGBoost),生物信息学,分子对接和分子动力学模拟.
- 识别和分析潜在的SDA目标和丰富的途径.
- 使用结直肠癌数据集 (GSE52060) 和诊断分析 (ROC) 的验证.
主要成果:
- 确定了191个潜在的SDA目标,丰富了癌症和动脉样硬化途径.
- 通过机器学习,Met原型瘤基因 (Met) 被确定为核心目标.
- 在患有凝血功能障碍和强诊断值 (AUC=0.856) 的患者中观察到升高的Met表达,证实了稳定的SDA-Met结合.
结论:
- 这项研究为了解SDA在凝血功能障碍中的作用提供了一个计算框架.
- 甲基原瘤基因 (Met) 是一个关键的分子标,涉及到SDA诱导的凝血异常.
- 这些发现支持未来对环境污染物引起的血液学疾病的预防和治疗策略的开发.
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