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血液恶性瘤患者多微生物血流感染的临床和微生物学特征:一个横截面研究

Nur Oğuz Davutoğlu¹, Cihan Yeşil², Burak Ekrem Çitil³

¹Division of Hematology, Faculty of Medicine, Muğla Sıtkı Koçman University, Muğla, 48000, Türkiye.

BMC infectious diseases

|January 22, 2026

概括

在患有血液性恶性瘤的患者中,多微生物血流感染 (PBSI) 的死亡率很高. 糟糕结果的关键风险因素包括ICU入院和机械通风,需要立即使用广谱抗生素.

科学领域:

传染性疾病传染性疾病
血液学血液学血液学
关键护理医学关键护理医学

背景情况:

血液恶性瘤和化疗导致严重的免疫功能障碍,增加感染风险.
血流感染 (BSI),特别是多微生物血流感染 (PBSI),是这些患者高死亡率的关键并发症.

研究的目的:

调查血液恶性瘤和PBSI患者临床结果不佳的风险因素.
提出潜在的解决方案,以减轻与PBSI相关的死亡率.

主要方法:

在Muğla教育和研究医院从2017年至2024年的医疗记录的回顾性审查.
对108名患者的人口统计数据,实验室结果,微生物分离物,抗生素敏感性和死亡结果的分析.
PBSI定义为在感染开始后72小时内隔离≥2种细菌物种.

主要成果:

21.4%的患者患有PBSI,凝血酶阴性葡萄球菌,Klebsiella spp.和Pseudomonas aeruginosa作为常见的病原体.
在58.3%的PBSI病例中发现了多重耐药生物;死亡率为57.1%.
死亡风险因素包括ICU入院,机械呼吸,腹腔营养,功能衰竭和肺炎.

结论:

在化疗治疗的血液性恶性瘤患者中,PBSI显著增加了发病率和死亡率.
建议包括尽量减少ICU住院,使用导管/通风器,优先考虑肠道营养,及时服用广谱抗生素.
多中心,前性研究对于优化治疗和减少PBSI死亡率至关重要.

关键词:

血液的恶性瘤.在MBSI中,它是MBSI.多种药物耐药性多种药物耐药性在PBSI中,PBSI是PBSI.

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