在肝细胞癌中用于单光子发射计算机断层扫描成像的新型FGFR4向
Qiurong Ju1, Xiaohui Wang1, Yutong Chen1
1State Key Laboratory of Natural Medicine, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, No. 24 Tongjia Lane, Gulou District, Nanjing 211198, China.
一种新的放射性追踪器,99mTc-HYNIC-FYQ-8,准纤维细胞生长因子受体4 (FGFR4). 这种基于的探针在临床前模型中显示出可用于成像FGFR4过度表达瘤的前景.
科学领域:
- 在瘤学瘤学.
- 放射化学 放射化学是指辐射化学.
- 分子成像学分子成像学
背景情况:
- 纤维细胞生长因子受体4 (FGFR4) 的过度表达在许多癌症中很常见.
- FGFR4是癌症诊断和治疗的潜在目标.
研究的目的:
- 开发和评估一种针对FGFR4.4的新型-放射性核酸结合物 (PRC).
- 评估开发的PRC对FGFR4表达瘤的诊断潜力.
主要方法:
- 使用高亲和性联体 (FYQ-8) 设计FGFR4向的PRC.
- 使用HYNIC结合技术-99m (99mTc) 对FYQ-8进行放射性标记.
- 在高表达FGFR4细胞系和异种移植模型中评估放射性追踪剂 (99mTc-HYNIC-FYQ-8).
主要成果:
- FYQ-8对FGFR4阳性细胞具有很高的结合亲和力.
- 放射性追踪器99mTc-HYNIC-FYQ-8在体内显示了高FGFR4表达瘤的特定吸收.
- 在异种移植模型中实现了瘤的高对比成像.
结论:
- 99mTc-HYNIC-FYQ-8是一种针对FGFR4.4的特定和有效的放射追踪器.
- 这种基于的放射性追踪剂有可能用于FGFR4过度表达的恶性瘤的临床成像.
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