手术更年期后24个月的性功能,活动和痛苦:更年期后发生的事情 (WHAM) - 一项前性受控研究
Martha Hickey1, Trevor Tejada-Berges2, Susan M Domchek3
1Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne and the Royal Women's Hospital, Melbourne, Victoria, Australia.
BJOG : an international journal of obstetrics and gynaecology
|January 23, 2026
概括
降低风险的卵管切除术 (RRSO) 显著增加女性的性功能障碍和痛苦. 激素替代疗法 (HRT) 在RRSO手术后没有改善性功能.
科学领域:
- 妇科 妇科 妇科 妇科
- 在瘤学瘤学.
- 性健康 性的健康
背景情况:
- 降低风险的卵管切除术 (RRSO) 是对卵巢和卵巢管癌风险较高的妇女的手术干预.
- 由RRSO引起的手术更年期会导致显著的生理变化,影响妇女健康的各个方面.
研究的目的:
- 评估RRSO对女性性功能的影响.
- 研究激素替代疗法 (HRT) 在RRSO后对性功能的潜在修饰作用.
主要方法:
- 一项前性观察性研究,将接受RRSO的女性与年龄相匹配的对照组进行比较.
- 性功能使用经过验证的问卷进行评估,包括女性性功能指数 (FSFI),法洛菲尔德性活动问卷 (SAQ) 和女性性困境量表修订 (FSDS-R) 在多个时间点,直至手术后24个月.
主要成果:
- 接受RRSO的女性经历了性功能障碍的显著增加,在24个月后从19%上升到42%,而对照组的增加较小.
- 性功能的关键方面,包括欲望,兴奋,滑和满意度在RRSO后显著减少. 性疼痛和不适也增加了.
- 在RRSO组中,性困扰几乎增加了四倍. 激素替代疗法 (HRT),用于RRSO患者的61%,没有显示与改善性功能,活动或痛苦的关联.
结论:
- RRSO导致性功能障碍和性困扰的显著增加.
- 激素替代疗法 (HRT) 似乎没有减轻RRSO对性功能的负面影响.
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