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基于便DNA的SDC2甲基化试验用于查无症状,平均风险人群中的结肠直肠新生病

Hyoung Il Choi¹, Jae Myung Cha^1,2, Young Sang Kim³

¹Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, Seoul, Korea.

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi

|January 23, 2026

概括

使用Syndecan-2甲基化 (meSDC2) 的便DNA测试显示,在平均风险人群中,对结直肠癌 (CRC) 查有前途. 这项现实研究发现结直肠瘤的高积极预测值,支持其在查计划中的使用.

科学领域:

在瘤学瘤学.
胃肠病学胃肠病学
分子诊断学分子诊断学

背景情况:

计划性结直肠癌 (CRC) 查对于平均风险人群至关重要.
以便DNA为基础的Syndecan-2甲基化 (meSDC2) 测试的诊断性能以前仅限于病例控制或高风险研究.
需要对平均风险个体的meSDC2测试有效性的真实数据.

研究的目的:

评估基于便DNA的meSDC2测试用于CRC检测的临床性能.
在平均风险人群中评估结直肠瘤 (CRN) 的阳性率,结直肠镜附着性和阳性预测值 (PPV).
为了确定meSDC2测试在现实世界查环境中的实用性.

主要方法:

追溯性多中心研究,涉及无症状,平均风险的个体接受CRC查.
分析了4910名完成meSDC2便测试的人员的数据.
在阳性meSDC2测试后评估结肠镜符合性和CRN的PPV.

主要成果:

在meSDC2测试中,阳性率为5.1% (249/4,910).
阳性测试后结肠镜合规率为61.0%.
对于任何CRN,晚期瘤和CRC的PPV分别为39.7%,12.4%和2.5%. 一个CRC的家族史预测了更高的CRN检测.

结论:

基于便DNA的meSDC2测试表明,在现实环境中,在平均风险人群中检测结直肠瘤的PPV很高.
这些发现支持meSDC2测试作为程序化CRC查的有价值工具的潜力.
该研究强调了现实世界数据对于验证查方式的重要性.

关键词:

生物标志物生物标志物结直肠瘤是什么意思通过DNA甲基化.便便便便进行大规模查.

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