使用中性粒细胞与淋巴细胞的比率和血小板与淋巴细胞的比率来评估牛皮的严重程度:系统性审查和元分析
Yi-Hsuan Shen1, Pei-Yun Ho1, Yu-Chen Huang1,2,3
1Department of Dermatology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Experimental dermatology
|January 23, 2026
概括
中性粒细胞与淋巴细胞的比率 (NLR) 和血小板与淋巴细胞的比率 (PLR) 在牛皮患者中升高. 这些比率可以帮助监测牛皮的严重程度和治疗的有效性.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
背景情况:
- 牛皮是一种慢性炎症性皮肤疾病,用于监测疾病严重程度和治疗反应的可靠生物标志物有限.
- 系统性炎症在牛皮病原发生过程中起着关键作用.
- 新的炎症标志物,如中性粒细胞与淋巴细胞的比率 (NLR) 和血小板与淋巴细胞的比率 (PLR),需要在牛皮中进行调查.
研究的目的:
- 评估NLR,PLR和牛皮之间的关联.
- 确定NLR和PLR是否可以作为疾病严重程度的指标.
- 评估NLR和PLR在监测牛皮治疗疗效方面的有用性.
主要方法:
- 在2025年5月之前对数据库进行系统的文献搜索.
- 纳入标准:比较牛皮中的NLR/PLR与对照者的研究,与牛皮重度区域指数 (PASI) 的相关性,以及生物治疗后的变化.
- 聚合数据的元分析.
主要成果:
- 与健康对照组相比,牛皮患者的NLR和PLR显著高于健康对照组 (SMD分别为0.645和0.467).
- 无论是NLR还是PLR,都显示出与PASI得分的显著正相关性 (分别r=0.214和0.161).
- 在3-4个月的生物疗法后,NLR和PLR水平显著下降,包括TNF-α抑制剂,乌斯特基努马布和IL-23抑制剂.
结论:
- 升高的NLR和PLR与牛皮有关.
- 根据PASI测量的NLR和PLR与牛皮的严重程度相关.
- NLR和PLR显示出作为可访问的生物标志物,用于监测牛皮治疗反应和全身炎症的潜力.
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