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了解共同感染的负担:COVID-19在被诊断和未被诊断的高级艾滋病毒患者的住院患者中

Anna E Tsygankova¹, Andrey N Gerasimov², Anton A Privalenko²

¹I.M. Sechenov First Moscow State Medical University (Sechenov University), Russian Federation; Moscow, Russia.

Current HIV research

|January 23, 2026

概括

对于患有晚期艾滋病毒和COVID-19的患者,机械通风,深刻的免疫抑制和高艾滋病毒病毒载量显著增加死亡风险. 早期识别高风险个体对于及时干预和改善结果至关重要.

科学领域:

传染性疾病传染性疾病
免疫学免疫学免疫学
公共卫生公共卫生

背景情况:

在SARS-CoV-2大流行期间,关注高风险群体.
艾滋病毒感染的免疫抑制个体 (PLWH) 是一个脆弱的人群.
该研究调查了晚期艾滋病毒患者严重COVID-19结局的风险因素.

研究的目的:

在晚期艾滋病毒患者中确定不利的COVID-19结果的风险因素.
为临床管理制定基于风险的优先级算法.
提高高风险患者及时进入ICU和开始治疗的速度.

主要方法:

基于人口普查的500名住院患者的样本分析,这些患者患有先进的艾滋病毒和中度至重度的COVID-19.
在莫斯科的传染病医院从2020-2022年收集的数据.
纳入标准:年龄大于18岁,确诊的艾滋病毒已晚期,确诊的COVID-19.

主要成果:

总的死亡率为27.0%.
死亡率的主要预测因素:机械呼吸 (aOR 4.29),严重的免疫抑制 (CD4+ <50细胞/毫米3,aOR 3.28) 和高的HIV病毒载量 (>20,000副本/毫升,aOR 3.37).
新诊断的艾滋病毒患者的死亡率更高 (46.2%);机会性感染 (卡波西肉瘤,肺囊炎肺炎,CMV肺炎) 的预后更糟. 保护因素包括保持免疫力 (CD4+>500) 和病毒抑制.

结论:

这些发现支持基于风险的优先级算法,用于COVID-19患者的高级HIV.
早期识别高风险患者有助于及时的ICU入院和治疗.
这种方法旨在改善临床管理和患者的治疗结果.

关键词:

在 COVID-19 疫情中,卡波西的肉瘤.这是PCP的PCP.这就是SARS-CoV-2病毒.先进的艾滋病病毒病毒.有关风险因素的风险因素.

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