电针与贝瓦西祖马布水凝结合,为膀癌提供治疗策略
Lisha Liu1,2, Ting Liang3, Guixiao Huang1
1Institute of Urology, Precision Medicine Laboratory, The Third Affiliated Hospital of Shenzhen University (Shenzhen Luohu People's Hospital), Shenzhen University, Shenzhen 518116, China.
ACS applied materials & interfaces
|January 23, 2026
概括
电针 (EA) 有效地抑制了膀癌的生长,并通过调节瘤免疫微环境来提高存活率. 将EA与抗血管原治疗结合起来,有望改善癌症治疗.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 传统中国医药 传统中国医药
背景情况:
- 针是中国传统医学 (TCM) 的一个关键组成部分,正在探索其在癌症治疗中的潜力.
- 针的精确机制,特别是电针 (EA),在像膀癌 (BC) 这样的固体瘤中需要进一步阐明.
研究的目的:
- 在膀癌 (BC) 鼠标模型中评估电 (EA) 的抗瘤疗效.
- 研究EA对瘤免疫微环境 (TIME) 和器官保护的影响的潜在机制.
- 开发和评估一种涉及EA和抗血管原体的组合疗法.
主要方法:
- 使用一个BC小鼠模型,用多克索鲁比 (DOX) 和EA治疗.
- 进行RNA测序 (RNA-seq) 和网络药理学,以探索机制.
- 进行单细胞RNA测序 (scRNA-seq) 来分析TIME异质性.
- 开发并测试了一种用于组合治疗的酸 (HA) @酸 (SA) - 贝瓦西祖马布 (BEV) 水凝.
主要成果:
- DOX和EA都显著抑制了瘤生长和延长了生存时间.
- EA增加了免疫细胞的比例,激活了CD8+ T细胞,抑制了血管生成,并减少了促炎性细胞因子.
- 该HA@SA-BEV水凝在瘤微环境中表现出稳定的药物释放.
- 联合EA和HA@SA-BEV疗法有效抑制了BC进展,增强了抗瘤功效.
结论:
- 通过调节瘤免疫微环境并提供器官保护,EA在膀癌中显示出显著的抗瘤疗效.
- EA显示了与抗血管原体药物联合治疗的潜力.
- 开发的HA@SA-BEV水凝与EA结合,为增强膀癌治疗提供了一个有希望的策略.
相关概念视频
01:23Urinary Bladder
3.3K
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
3.3K
01:13Therapeutic Index
6.7K
The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
6.7K
01:30Therapeutic Communication
7.7K
Communication is a lifelong learning process. Through therapeutic communication, nurses can collect relevant assessment data, provide education and counseling, and interact during nursing interventions. Sending and receiving messages occur through verbal and nonverbal communication techniques and can happen separately or simultaneously.
Verbal communication depends on language or a prescribed way of using words so that people can share information effectively. The critical aspects of verbal...
Verbal communication depends on language or a prescribed way of using words so that people can share information effectively. The critical aspects of verbal...
7.7K
01:19Anatomy of the Genitourinary System II: Bladder and Urethra
1.5K
The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
1.5K
01:29Microorganisms in Medicine and Therapeutics
1.0K
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.0K
01:26Cholinergic Antagonists: Therapeutic Uses
1.4K
Antimuscarinic drugs have various therapeutic applications by inhibiting parasympathetic stimulation in different systems. Here are the key therapeutic uses of antimuscarinics:
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal...
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal...
1.4K