在先进的默克尔细胞癌中使用Avelumab的现实世界:系统性审查和非比较性元分析
Andreas Freitag1, Zhiyi Lan2, Hoora Moradian2
1Evidence, Value & Access, Cytel, Inc., London, UK.
Future oncology (London, England)
|January 23, 2026
概括
现实世界的证据表明,阿维卢马布在先进的默克尔细胞癌 (MCC) 中提供了显著的生存益处. 这种免疫疗法在MCC患者中显示出强的12个月整体生存率和无进展生存率.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 现实世界的证据.
背景情况:
- 编程死亡 (连接体) 1 抑制剂是先进的默克尔细胞癌 (MCC) 的一线治疗方法.
- 对于先进的MCC免疫疗法,有限的比较试验需要现实世界的证据 (RWE) 合成.
研究的目的:
- 系统地识别和综合RWE在先进的MCC中免疫疗法的有效性和安全性.
- 评估接受免疫治疗的局部晚期或转移性MCC患者的现实结果.
主要方法:
- 在 MEDLINE 和 Embase 搜索了关于高级 MCC 的观察性 RWE 研究 (2017 年 1 月至 2023 年 12 月).
- 对Avelumab进行了12个月总生存期 (OS) 和无进展生存期 (PFS) 的元分析.
- 从包括的回顾性研究中评估了安全数据.
主要成果:
- 阿维卢马布是唯一具有足够数据进行元分析的免疫疗法.
- 综合12个月的OS率为77.7% (第三阶段) 和63.0% (第四阶段) MCC.
- 聚合12个月的PFS率为53.3% (第三阶段) 和39.3% (第四阶段) MCC.
结论:
- 现实世界的数据支持阿维卢马布在高级MCC中的有效性.
- 阿维卢马布的生存结果与临床试验数据相似.
- 在现实环境中的安全概况似乎是有利的,因此需要更广泛的使用.
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