一个随机对照试验的长期跟踪对母乳个性化强化进行了长期跟踪
Meiying Quan1, Yu Zhang1, Lejia Zhang1
1Department of Pediatrics, State Key Laboratory of Complex Severe and Rare Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Frontiers in nutrition
|January 23, 2026
概括
在早产婴儿的个性化强化 (IF) 改善了早期生长标志物. 然而,与标准强化 (SF) 相比,没有观察到显著的长期健康或发育差异.
科学领域:
- 新生儿营养新生儿营养
- 儿科生长和发育的发展.
- 临床营养研究临床营养研究
背景情况:
- 之前的随机对照试验 (RCT) 针对早产婴儿的个性化强化 (IF).
- 需要评估IF的短期和长期成果.
研究的目的:
- 评估接受个性化强化 (IF) 的早产婴儿的短期 (长达2年) 和长期 (6-10年) 结果.
- 为了比较IF和标准强化 (SF) 组之间的生长,发育和生化标志物.
主要方法:
- 来自北京联合医学院医院 (PUMCH) IF研究的早产婴儿的回顾性分析.
- 数据收集包括高达2岁的医疗记录和6-10岁的长期随访.
- 在IF和SF组之间比较生长参数,生化指数,肺功能,认知得分和代谢概况.
主要成果:
- 51名婴儿完成了2年的随访;IF组在6个月后改善了头周z-score,12个月后改善了血红蛋白,24个月后改善了体重z-score.
- 25名儿童完成了长期随访.
- 在长期肺功能,认知评分,生化标志物 (费里丁,血红蛋白,IGF,25-OH-维生素D),骨年龄或代谢参数 (BMI,脂质概况) 中没有发现显著差异.
结论:
- 个性化强化 (IF) 对早产婴儿的早期生长结果有明显的益处.
- 与标准强化 (SF) 相比,IF在10岁之前没有观察到长期健康或发育方面的显著优势.
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