评估维生素D增强在2型糖尿病中糖度指数的效力:一个元分析
1Department of Clinical Nutrition, Zhuzhou City Central Hospital, Zhuzhou, Hunan, China.
Frontiers in nutrition
|January 23, 2026
概括
维生素D补充剂有效地增加了2型糖尿病患者的维生素D水平,但没有改善血糖控制或胰岛素抵抗. 治疗耐受性良好,与安慰剂相似的安全性.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 营养科学 营养科学
背景情况:
- 2型糖尿病 (T2D) 是一个全球性的健康问题.
- 维生素D缺乏症在T2D患者中很普遍.
- 维生素D补充剂在T2D管理中的作用受到辩论.
研究的目的:
- 评估维生素D补充剂对T2D中血糖控制的疗效.
- 评估维生素D对胰岛素耐药性的影响.
- 为了确定维生素D在T2D中的耐受性和安全性.
主要方法:
- 进行了随机对照试验 (RCT) 的元分析.
- 搜索包括主要的科学数据库 (PubMed,Embase,科学网络,Cochrane,CNKI,万芳).
- 符合条件的RCT涉及接受维生素D的成人T2D患者,测量HbA1c,HOMA-IR或25(OH) D.
主要成果:
- 分析了10个带有3,460名参与者的RCT.
- 维生素D补充剂显著增加了血清25(OH) D水平 (SMD:4.01).
- 在HbA1c (SMD:0.08) 或HOMA-IR (SMD:5.95) 中没有发现显著改善.
- 维生素D和对照组之间的不良事件是相似的 (RR: 1.19).
结论:
- 维生素D补充剂在T2D中提高了25(OH) D水平,但没有改善血糖控制或胰岛素敏感性.
- 补充剂被很好地容忍,具有良好的安全性.
- 未来的研究应该基于基线维生素D状态,剂量和持续时间来探索影响.
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