在患有眼膜扩散大B细胞淋巴瘤的患者中,视觉预后和生存结果
Sirawit Wainipitapong1, Orapan Aryasit1, Panarat Noiperm2
1Department of Ophthalmology, Faculty of Medicine, Prince of Songkla University, Kohong, Hat Yai, Songkhla 90110, Thailand.
International journal of ophthalmology
|January 23, 2026
概括
眼部附带扩散大B细胞淋巴瘤 (OA-DLBCL) 经常呈现出晚期疾病. 低生存率与,心血管疾病,艾滋病毒,M1阶段和二次OA-DLBCL有关,突出显示需要更好的治疗方法.
科学领域:
- 在瘤学瘤学.
- 眼科医生 眼科 眼科
- 血液学 血液学 血液学
背景情况:
- 眼部附带扩散大B细胞淋巴瘤 (OA-DLBCL) 是一种罕见的外节非霍奇金淋巴瘤.
- 了解临床特征和生存结果对于有效管理至关重要.
- 关于影响OA-DLBCL患者整体存活时间 (OS) 的预后因素的数据有限.
研究的目的:
- 研究OA-DLBCL.的临床特征和治疗结果.
- 分析影响OA-DLBCL患者视觉功能和整体存活时间 (OS) 的因素.
- 确定OA-DLBCL中生存的独立预后因素.
主要方法:
- 对29名通过组织病理活检诊断的OA-DLBCL患者进行了回顾性队列研究 (2006-2023年).
- 患者分为初级OA-DLBCL和二级OA-DLBCL亚组.
- 卡普兰-梅尔生存分析方法;多变量考克斯回归用于预后因素识别.
主要成果:
- 该队列包括24例初级和5例二级OA-DLBCL病例.
- 50%的原发性OA-DLBCL患者患有晚期疾病 (Ann Arbor阶段IIIE-IV);66%患有T4 TNM阶段.
- 糟糕的生存因素包括,动脉样硬化心血管疾病,艾滋病毒感染,M1阶段和二次OA-DLBCL (所有P<0.05).
结论:
- 初级OA-DLBCL经常在晚期出现.
- ,心血管疾病,艾滋病毒,M1阶段和二次OA-DLBCL是生存率差的独立预测因素.
- 优化治疗策略和早期查对于改善OA-DLBCL管理至关重要,特别是在发展中国家.
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