在慢性失眠障碍中,灰色物质结构共变网络的破坏
Zhonglin Li1, Yu Shen1,2, Jiao Liu3
1Department of Radiology, Henan Provincial People's Hospital & People's Hospital of Zhengzhou University, Zhengzhou, China.
Frontiers in psychiatry
|January 23, 2026
概括
慢性失眠障碍会改变大脑结构和网络连接. 这项研究揭示了感觉运动区域灰色物质体积和网络枢纽的变化,为疾病的机制提供了新的见解.
科学领域:
- 神经科学是一个神经科学.
- 脑部成像 脑部成像
- 睡眠医学 睡眠医学
背景情况:
- 慢性失眠障碍 (CID) 与灰质体积 (GMV) 和结构连接性变化有关.
- 在CID中,结构共变网络 (SCN) 的拓性质尚不清楚.
研究的目的:
- 在CID患者中调查基于GMV的SCN的拓特征.
- 探索GMV,SCN拓和失眠严重程度之间的关系.
主要方法:
- 基于voxel的形态测量和图形理论用于分析82名CID患者和73名对照者的SCN.
- 评估了GMV,SCN拓和匹兹堡睡眠质量指数 (PSQI) 的得分,控制了共变量.
- 分析了网络枢纽和节点属性 (中间中心性,程度,效率).
主要成果:
- 双边前中心 (PreCG) 的GMV增加与PSQI得分负相关.
- 患有CID的患者在右侧中心叶 (PCL) 和左侧中心叶后回形 (PoCG) 中表现出改变的结节性质.
- 网络枢纽在改变节点参数的区域被重新配置.
结论:
- 在CID中睡眠障碍与感觉运动区域的GMV和SCN拓异常有关.
- 这些发现为了解CID病理生理学提供了新的方向.
- 在PCL和PoCG中改变的网络枢纽与CID有关.
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